다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

https://imechanica.org/files/Qiu_environmental_sensitive_hydrogel.pdf

Environment-sensitive hydrogels for drug delivery

Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc) in the treatment of various diseases The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (eg, natural products) and selective diagnosis through disease marker molecules The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed In addition, we have included information regarding the trends and perspectives in nanomedicine area

/pdf/nano-based-drug-delivery-systems-recent-developments-and-2xpm2mog5c.pdf

Nano based drug delivery systems: recent developments and future prospects

https://centaur.reading.ac.uk/38544/10/1-s2.0-S0014305714004091-main%20%281%29.pdf

Biomedical applications of hydrogels: A review of patents and commercial products

Hydrogel Nanoparticles in Drug Delivery

Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medicinal properties such as analgesic, sedative, anti-inflammatory, spasmolytic, and locally anaesthetic remedies. In this review their nanoencapsulation in drug delivery systems has been proposed for their capability of decreasing volatility, improving the stability, water solubility, and efficacy of essential oil-based formulations, by maintenance of therapeutic efficacy. Two categories of nanocarriers can be proposed: polymeric nanoparticulate formulations, extensively studied with significant improvement of the essential oil antimicrobial activity, and lipid carriers, including liposomes, solid lipid nanoparticles, nanostructured lipid particles, and nano- and microemulsions. Furthermore, molecular complexes such as cyclodextrin inclusion complexes also represent a valid strategy to increase water solubility and stability and bioavailability and decrease volatility of essential oils.

/pdf/essential-oils-loaded-in-nanosystems-a-developing-strategy-18rgf2kl0z.pdf

Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach

70 years have passed since the first isolation of the naphthodianthrones hypericin and pseudohypericin from Hypericum perforatum L. Today, they continue to be one of the most promising group of polyphenols, as they fascinate with their physical, chemical and important biological properties which derive from their unique chemical structure. Hypericins and their derivatives have been extensively studied mainly for their antitumor, antiviral and antidepressant properties. Notably, hypericin is one of the most potent naturally occurring photodynamic agents. It is able to generate the superoxide anion and a high quantum yield of singlet oxygen that are considered to be primarily responsible for its biological effects. The prooxidant photodynamic properties of hypericin have been exploited for the photodynamic therapy of cancer (PDT), as hypericin, in combination with light, very effectively induces apoptosis and/or necrosis of cancer cells. The mechanism by which these activities are expressed continues to be a main topic of discussion, but according to scientific data, different modes of action (generation of ROS & singlet oxygen species, antiangiogenesis, immune responces) and multiple molecular pathways (intrinsic/extrinsic apoptotic pathway, ERK inhibition) possibly interrelating are implicated. The aim of this review is to analyse the most recent advances (from 2005 and thereof) in the chemistry and biological activities (in vitro and in vivo) of the pure naphthodianthrones, hypericin and pseudohypericin from H. perforatum. Extracts from H. perforatum were not considered, nor pharmakokinetic or clinical data. Computerised literature searches were performed using the Medline (PubMed), ChemSciFinder and Scirus Library databases. No language restrictions were imposed.

https://www.mdpi.com/1422-0067/11/2/562/pdf

Hypericins as potential leads for new therapeutics.

Extracts from Bupleurum fruticescens were examined for oral and topical anti-inflammatory activities. The BuOH extract proved to be active against carrageenan and tetradecanoylphorbol acetate acute edemas and allowed the isolation of three saponins identified by spectroscopic techniques as 3 beta-O-(O-alpha-L-rhamnopyranosyl-(1-->4)-O-[beta-D-glucopyranosyl- (1-->6)]-O-beta-D-glucopyranosyl)lup-20(29)-ene-23,28-dioic acid (fruticesaponin A), 3 beta-O-(O-alpha-L-rhamnopyranosyl-(1-->4)-O-beta-D-glucopyranosyl) lup-20(29)-ene-23,28-dioic acid 28-O-beta-D-glucopyranosyl ester (fruticesaponin B), and 3 beta-O-(O-alpha-L-rhamnopyranosyl-(1-->4)-O-[beta-D-glucopyranosyl- (1-->6)]-O-beta-D-glucopyranosyl)-lup-20(29)-ene-23,28-dioic acid 28-O-beta-D-glucopyranosyl ester (fruticesaponin C). These compounds were studied against carrageenan, tetradecanoylphorbol acetate, arachidonic acid and ethyl phenylpropiolate acute edemas. Fruticesaponin B, a bidesmosidic saponin with an unbranched saccharide moiety was the most active in all the tests applied.

Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens

St. John's wort and depression: Efficacy, safety and tolerability-an update

The protein coded by the open-reading-frame 3a of SARS coronavirus has been
 demonstrated to form a cation-selective channel that may become expressed in
 the infected cell. The activity of the channel is involved in the mechanism
 of virus release. Drugs that inhibit the ion channel can, therefore, inhibit
 virus release, and they could be a source for development of novel
 therapeutic antiviral agents. Various drugs found in Chinese herbs that are
 well known as anticancer agents also have an antiviral potency. Here we
 tested the flavonols kaempferol, kaempferol glycosides, and acylated
 kaempferol glucoside derivatives with respect to their potency to block the
 3a channel. We used the Xenopus oocyte with a heterologously
 expressed 3a protein as a model system to test the efficacy of the
 flavonols. Some of these drugs turned out to be potent inhibitors of the 3a
 channel. The most effective one was the glycoside juglanin (carrying an
 arabinose residue) with an IC50 value of 2.3 µM for inhibition of
 the 3a-mediated current. Kaempferol derivatives with rhamnose residue also
 seem to be quite effective. We suggest that viral ion channels, in general,
 may be a good target for the development of antiviral agents, and that, in
 particular, kaempferol glycosides are good candidates for 3a channel
 proteins of coronaviruses.

/pdf/kaempferol-derivatives-as-antiviral-drugs-against-the-3a-75c8o1v83v.pdf

Anna Rita Bilia

Papers

Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach

Hypericins as potential leads for new therapeutics.

Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens

St. John's wort and depression: Efficacy, safety and tolerability-an update

Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus.