Anna Rita Migliaccio

TL;DR: GATA1 is indispensable mainly for erythroid and megakaryocyte differentiation and its deficiency results in apoptosis, and the current understanding of the functions of GATA1 in normal hematopoiesis and how it is altered in disease is reviewed.

TL;DR: The amplification potential of CD34+ cord blood cells in liquid cultures stimulated with SCF in combination with interleukin-3 (IL-3), erythropoietin (Epo) or granulocyte colony-stimulating factor (G-CSF) under serum-deprived conditions is analyzed to highlight the high proliferative and differentiative potential of cord blood stem cells.

TL;DR: The data provide an unanticipated mechanism for autosomal dominant inherited polycythemia due to a heterozygous EPOR mutation and suggest a regulatory role of EPO/EPOR pathway in human circulating endothelial precursors homeostasis.

TL;DR: The Theory of calreticulin as an intrinsically disordered protein is illustrated and the Hypothesis that the dynamic conformational changes to which cal reticulin may be subjected by environmental cues, by promoting or restricting the exposure of its active sites, may affect its function under normal and pathological conditions is discussed.

TL;DR: The present study shows that gamma-irradiated TALL-104 cells, cultured for 18 hours with marrows from healthy donors, do not impair the viability and long-term growth of committed and pluripotent hematopoietic progenitors, and indicates the strong potential of the Tall-104 cell line in future marrow purging strategies against lysis-susceptible and -resistant leukemias.