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Anna Skwarska
Researcher at Gdańsk University of Technology
Publications - 21
Citations - 5516
Anna Skwarska is an academic researcher from Gdańsk University of Technology. The author has contributed to research in topics: Programmed cell death & Biology. The author has an hindex of 9, co-authored 16 publications receiving 5031 citations. Previous affiliations of Anna Skwarska include Medical University of Białystok.
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DNA-Damaging Imidazoacridinone C-1311 Induces Autophagy followed by Irreversible Growth Arrest and Senescence in Human Lung Cancer Cells
TL;DR: It is suggested that in NSCLC, a C-1311–induced senescence program is preceded and corroborated but not exclusively determined by the induction of autophagy, and a small interfering RNA–mediated knockdown of theAutophagy-associated Beclin 1 and ATG5 genes attenuated but failed to block development ofsenescence.
Journal Article
Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
TL;DR: Surprisingly, simultaneous exposure of pancreatic cancer cells to C-1748 in combination with the late-stage autophagy inhibitor, chloroquine, neither significantly increased the cytotoxic activity of C- 1748 nor ameliorated its apoptosis-inducing potential.
Journal ArticleDOI
Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering.
TL;DR: A successful fabrication of the microporous polyurethane thin layer (MPTL) of 1 mm thick is reported, which was produced using SC/PL technique combined with phase separation (PS), which can be considered a suitable scaffold for tissue engineering purpose, according to the morphology criterion.
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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
Natalia Baran,Alessia Lodi,Yogesh Dhungana,Shelley M. Herbrich,Meghan Collins,Shannon R. Sweeney,Renu Pandey,Anna Skwarska,S. Patel,Mathieu Tremblay,Vinitha Mary Kuruvilla,Antonio Cavazos,Mecit Kaplan,Marc O. Warmoes,Diogo F.T. Veiga,Kenichi Furudate,Shanti Rojas-Sutterin,André Haman,Yves Gareau,Anne Marinier,Helen Ma,Karine Harutyunyan,May Daher,Lucia Garcia,Gheath Alatrash,Sujan Piya,Vivian Ruvolo,Wentao Yang,Sriram S. Shanmugavelandy,Ningping Feng,J. Gay,Di Du,Jun Yang,Fieke W Hoff,Marcin Kamiński,Katarzyna Tomczak,R. Eric Davis,Daniel Herranz,Adolfo A. Ferrando,Elias Jabbour,M. Emilia Di Francesco,David T. Teachey,Terzah M. Horton,Steven M. Kornblau,Katayoun Rezvani,Guy Sauvageau,Mihai Gagea,Michael Andreeff,Koichi Takahashi,Joseph R. Marszalek,Philip L. Lorenzi,Jiyang Yu,Stefano Tiziani,Trang Hoang,Marina Konopleva +54 more
TL;DR: In this article , the authors identify OxPhos as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NotCH1, elevated Oxphos gene expression, and acquired chemoresistance in pre-leukemic and leukemic models.
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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells.
Anita Wiśniewska,Magdalena Niemira,Karolina Jagiello,Agnieszka Potęga,Małgorzata Świst,Colin J. Henderson,Anna Skwarska,Ewa Augustin,Jerzy Konopa,Zofia Mazerska +9 more
TL;DR: The crucial role of hypoxic conditions and the direct involvement of POR in the metabolism of both compounds were demonstrated and the low reactivity of C-1748 and the stability of its metabolites are postulated to contribute significantly to the diminished toxicity of this compound observed in animals.