T
Trang Hoang
Researcher at Université de Montréal
Publications - 80
Citations - 9498
Trang Hoang is an academic researcher from Université de Montréal. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 38, co-authored 75 publications receiving 8886 citations. Previous affiliations of Trang Hoang include University of Toronto & Laboratory of Molecular Biology.
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Journal ArticleDOI
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
Tsvee Lapidot,Christian Sirard,Josef Vormoor,Barbara Murdoch,Trang Hoang,Julio R. Caceres-Cortes,Mark D. Minden,Bruce Paterson,Michael A. Caligiuri,John E. Dick +9 more
TL;DR: This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells.
Journal ArticleDOI
Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement
Geoffrey Hale,Susan Bright,Gill Chumbley,Trang Hoang,Donald Metcalf,A. J. Munro,Herman Waldmann +6 more
TL;DR: A new rat monoclonal antibody, CAMPATH 1, which is suitable for depleting lymphocytes from human marrow grafts, and an IgM that fixes human complement is described, which could potentially be applied to other experimental and clinical situations where depletion of lymphoid cells is required.
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Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
Gerard Brady,Filio Billia,Jennifer J. Knox,Trang Hoang,Ilan R. Kirsch,Evelyn B. Voura,Robert G. Hawley,Robert C. Cumming,Manuel Buchwald,Kathy Siminovitch,Neil G. Miyamoto,Guido Boehmelt,Norman N. Iscove +12 more
TL;DR: The results provide the first expression mapping of these genes that distinguishes between progenitors in different commitment states, generate new insights and predictions relevant to mechanism, and introduce a powerful set of tools for unravelling the genetic basis of lineage divergence.
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SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression.
TL;DR: It is shown that SCL and its partners are coexpressed in the most primitive thymocytes, and the gene encoding pTα is identified as a downstream target of HEB that is specifically repressed by the SCL-LMO complex.
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SCL: From the origin of hematopoiesis to stem cells and leukemia
Eric Lécuyer,Trang Hoang +1 more
TL;DR: Changes in composition of SCL-containing complexes may ensure flexibility and specificity in the regulation of lineage-specific programs of gene expression, thus providing the molecular basis through which SCL exerts its essential functions at several branch points of the hematopoietic hierarchy.