A
Annabel K. Short
Researcher at University of California, Irvine
Publications - 30
Citations - 754
Annabel K. Short is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Offspring & Medicine. The author has an hindex of 10, co-authored 22 publications receiving 455 citations. Previous affiliations of Annabel K. Short include Florey Institute of Neuroscience and Mental Health & University of California.
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Journal ArticleDOI
Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.
Annabel K. Short,K.A. Fennell,K.A. Fennell,Victoria M. Perreau,Andrew Fox,Moira K O'Bryan,Jee Hyun Kim,Timothy W. Bredy,Terence Y. Pang,Terence Y. Pang,Anthony J. Hannan,Anthony J. Hannan +11 more
TL;DR: Evidence is provided that sustained elevation of glucocorticoids is involved in the transmission of paternal stress-induced traits across generations in a process involving small noncoding RNA signals transmitted by the male germline.
Journal ArticleDOI
Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety.
Annabel K. Short,Shlomo Yeshurun,R Powell,Victoria M. Perreau,Andrew Fox,Jee Hyun Kim,Terence Y. Pang,Terence Y. Pang,Anthony J. Hannan,Anthony J. Hannan +9 more
TL;DR: It is believed that this is the first evidence that paternal exercise is associated with an anxiolytic behavioral phenotype of male offspring and altered levels of small noncoding RNAs in sperm.
Journal ArticleDOI
Early-life adversity and neurological disease: age-old questions and novel answers.
Annabel K. Short,Tallie Z. Baram +1 more
TL;DR: It is suggested that fragmented and unpredictable environmental and parental signals comprise a novel and potent type of adversity, which contributes to subsequent vulnerabilities to cognitive illnesses via mechanisms involving disordered maturation of brain ‘wiring’.
Journal ArticleDOI
Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance.
Matthew T. Birnie,Cassandra L. Kooiker,Annabel K. Short,Jessica L. Bolton,Yuncai Chen,Tallie Z. Baram +5 more
TL;DR: Focusing on amygdala nuclei and their projections, evidence is provided suggesting that aberrant CRF expression and function may underlie augmented connectivity of the nucleus accumbens with fear/anxiety regions, disrupting the function of this critical locus of pleasure and reward.
Journal ArticleDOI
Transgenerational paternal transmission of acquired traits: Stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes.
TL;DR: Understanding the mechanisms involved in such transgenerational effects may facilitate future screening of human sperm for 'epigenetic health' and the tailoring of therapeutic interventions according to genetic and epigenetic contributions to illness.