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Annapoorni Rangarajan
Researcher at Indian Institute of Science
Publications - 79
Citations - 6020
Annapoorni Rangarajan is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Cancer & AMPK. The author has an hindex of 29, co-authored 67 publications receiving 5370 citations. Previous affiliations of Annapoorni Rangarajan include Massachusetts Institute of Technology & Harvard University.
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Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
Annapoorni Rangarajan,Annapoorni Rangarajan,Claudio Talora,Ryuhei Okuyama,Michael Nicolas,Cristina Mammucari,Heysun Oh,Jon C. Aster,Sudhir Krishna,Daniel Metzger,Pierre Chambon,Lucio Miele,Michel Aguet,Freddy Radtke,G. Paolo Dotto +14 more
TL;DR: Keratinocyte‐specific deletion of the Notch1 gene results in marked epidermal hyperplasia and deregulated expression of multiple differentiation markers, and Notch signaling triggers two distinct pathways leading to keratinocyte growth arrest and differentiation.
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Correction: Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma
Aneesha Radhakrishnan,Vishalakshi Nanjappa,Remya Raja,Gajanan Sathe,Vinuth N Puttamallesh,Ankit P. Jain,Sneha M. Pinto,Sai A. Balaji,Sandip Chavan,Nandini A. Sahasrabuddhe,Premendu P. Mathur,Mahesh Kumar,T. S. Keshava Prasad,Vani Santosh,Geethanjali Sukumar,Joseph A. Califano,Annapoorni Rangarajan,David Sidransky,Akhilesh Pandey,Harsha Gowda,Aditi Chatterjee +20 more
TL;DR: This corrects the article DOI: 10.1038/srep36132 to indicate that the author of the paper is a doctor of medicine rather than a scientist, as previously reported.
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Comparative biology of mouse versus human cells: modelling human cancer in mice
TL;DR: There are fundamental differences in how the process of tumorigenesis occurs in mice and humans, and these differences affect the use of mice as models of human tumour pathogenesis.
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Species- and cell type-specific requirements for cellular transformation.
TL;DR: It is determined that perturbation of two signaling pathways-involving p53 and Raf-suffices for the tumorigenic conversion of normal murine fibroblasts, while perturbations of six pathways- involvingp53, pRb, PP2A, telomerase, Raf, and Ral-GEFs-is needed for human fibro Blasts.
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Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis.
Randolph S. Watnick,Yi Ning Cheng,Annapoorni Rangarajan,Tan A. Ince,Tan A. Ince,Robert A. Weinberg +5 more
TL;DR: A novel mechanism by which the cooperative activity of the oncogenes, ras and myc, leads directly to angiogenesis and tumor formation is described.