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Annarosa Leri
Researcher at Brigham and Women's Hospital
Publications - 202
Citations - 40256
Annarosa Leri is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Stem cell & Myocyte. The author has an hindex of 88, co-authored 202 publications receiving 39365 citations. Previous affiliations of Annarosa Leri include Cardiovascular Institute of the South & University of Milan.
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Journal ArticleDOI
The young mouse heart is composed of myocytes heterogeneous in age and function.
Marcello Rota,Toru Hosoda,Antonella De Angelis,Michael L. Arcarese,Grazia Esposito,Roberto Rizzi,Jochen Tillmanns,Derin Tugal,Ezio Musso,Ornella Rimoldi,Claudia Bearzi,Konrad Urbanek,Piero Anversa,Annarosa Leri,Jan Kajstura +14 more
TL;DR: Physiologically and structurally, observations at the physiological and structural cellular level document that by necessity the heart has to constantly repopulate its myocyte compartment to replace senescent poorly contracting myocytes with younger more efficient cells, which regulates cardiac function.
Journal ArticleDOI
Myocyte cell death and ventricular remodeling
TL;DR: The documentation that mechanical forces in vitro, mimicking diastolic Laplace overloading in vivo, can transmit a death signal to myocytes suggests that programmed cell death may be triggered in the stressed myocardium independently from the etiology of the overload.
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Inhibition of Notch1-Dependent Cardiomyogenesis Leads to a Dilated Myopathy in the Neonatal Heart
Konrad Urbanek,Mauricio C Cabral-Da-Silva,Noriko Ide-Iwata,Silvia Maestroni,Francesca Delucchi,Hanqiao Zheng,João Ferreira-Martins,Barbara Ogorek,Domenico D'Amario,Michael Bauer,Gianpaolo Zerbini,Marcello Rota,Toru Hosoda,Ronglih Liao,Piero Anversa,Jan Kajstura,Annarosa Leri +16 more
TL;DR: Notch1 signaling is a critical determinant of CSC growth and differentiation; when this cascade of events is altered, cardiomyogenesis is impaired, physiological cardiac hypertrophy is prevented, and a life-threatening myopathy supervenes.
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Cardiac stem cell niches
TL;DR: The relevance of Notch1 signaling, gap-junction formation, HIF-1α and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed.
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Origin of Cardiomyocytes in the Adult Heart
TL;DR: The recognition of the origin of cardiomyocytes is of critical importance for the development of strategies capable of enhancing the growth response of the myocardium; in fact, cell therapy for the decompensated heart has to be based on the acquisition of this fundamental biological knowledge.