Annarosa Leri

TL;DR: Human lungs contain identifiable stem cells that have the undemonstrated potential to promote tissue restoration in patients with lung disease and participate in tissue homeostasis and regeneration.

TL;DR: In a model of insulin-dependent diabetes mellitus, the generation of reactive oxygen species (ROS) leads to telomeric shortening, expression of the senescent associated proteins p53 and p16INK4a, and apoptosis of CPCs, impairing the growth reserve of the heart, suggesting that intact CPCs can effectively counteract the impact of uncontrolled diabetes on the heart.

TL;DR: The results indicate that BMCs engraft, survive, and grow within the spared myocardium after infarction by forming junctional complexes with resident myocytes, and BMCs transdifferentiate and acquire the cardiomyogenic and vascular phenotypes restoring the infarcted heart.

TL;DR: In vitro results support the notion that hyperglycemia with diabetes promotes myocyte apoptosis mediated by activation of p53 and effector responses involving the local renin-angiotensin system.

TL;DR: This research is focused on the capacity of BMSC to form new cardiac myocytes and coronary vessels following an induced myocardial infarct in adult mice and results in improved cardiac function and survival.