A
Annarosa Leri
Researcher at Brigham and Women's Hospital
Publications - 202
Citations - 40256
Annarosa Leri is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Stem cell & Myocyte. The author has an hindex of 88, co-authored 202 publications receiving 39365 citations. Previous affiliations of Annarosa Leri include Cardiovascular Institute of the South & University of Milan.
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Journal ArticleDOI
Pim-1 regulates cardiomyocyte survival downstream of Akt
John A. Muraski,Marcello Rota,Yu Misao,Jenna Fransioli,Christopher T. Cottage,Natalie Gude,Grazia Esposito,Francesca Delucchi,Michael L. Arcarese,Roberto Alvarez,Sailay Siddiqi,Gregory Emmanuel,Weitao Wu,Kimberlee M. Fischer,Joshua J. Martindale,Christopher C. Glembotski,Annarosa Leri,Jan Kajstura,Nancy S. Magnuson,Anton Berns,Remus M Beretta,Steven R. Houser,Erik Schaefer,Piero Anversa,Mark A. Sussman +24 more
TL;DR: Cardioprotective stimuli associated with Akt activation induced Pim-1 expression, but compensatory increases in Akt abundance and phosphorylation after pathological injury by infarction or pressure overload did not protect the myocardium in Pim–deficient mice, suggesting that PIM-1 is a crucial facet of cardioprotection downstream of Akt.
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Nuclear Targeting of Akt Enhances Kinase Activity and Survival of Cardiomyocytes
Isao Shiraishi,Jaime Melendez,Youngkeun Ahn,Maryanne Skavdahl,Elizabeth Murphy,Sara Welch,Erik Schaefer,Kenneth Walsh,Anthony Rosenzweig,Daniele Torella,Daria Nurzynska,Jan Kajstura,Annarosa Leri,Piero Anversa,Mark A. Sussman +14 more
TL;DR: Experiments show that targeting of Akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling, opening new possibilities for therapeutic applications of nuclear-targeted AkT to inhibit cell death associated with heart disease.
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Intracoronary Delivery of Autologous Cardiac Stem Cells Improves Cardiac Function in a Porcine Model of Chronic Ischemic Cardiomyopathy
Roberto Bolli,Xian Liang Tang,Santosh K. Sanganalmath,Ornella Rimoldi,Federico Mosna,Ahmed Abdel-Latif,Hani Jneid,Marcello Rota,Annarosa Leri,Jan Kajstura +9 more
TL;DR: The results mimic those recently reported in humans (Stem Cell Infusion in Patients with Ischemic CardiOmyopathy [SCIPIO] trial) and establish this porcine model of ischemic cardiomyopathy as a useful and clinically relevant model for studying CSCs.
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Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction
M. Elena Padin-Iruegas,Yu Misao,Michael Davis,Vincent F.M. Segers,Grazia Esposito,Tomotake Tokunou,Konrad Urbanek,Toru Hosoda,Marcello Rota,Piero Anversa,Annarosa Leri,Richard T. Lee,Jan Kajstura +12 more
TL;DR: The addition of nanofiber-mediated IGF-1 delivery to CPC therapy improved in part the recovery of myocardial structure and function after infarction.
Journal ArticleDOI
Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism
Toru Hosoda,Hanqiao Zheng,Mauricio C Cabral-Da-Silva,Fumihiro Sanada,Noriko Ide-Iwata,Barbara Ogorek,João Ferreira-Martins,Christian Arranto,Domenico D'Amario,Federica del Monte,Konrad Urbanek,David A. D'Alessandro,Robert E. Michler,Piero Anversa,Marcello Rota,Jan Kajstura,Annarosa Leri +16 more
TL;DR: The recognition that miR-499 promotes the differentiation of hCSCs into mechanically integrated cardiomyocytes has important clinical implications for the treatment of human heart failure.