Anne A. Wiley

TL;DR: That disruption of uterine development during critical organizational periods can alter the functional capacity and embryotrophic potential of the adult uterus reinforces the importance of understanding the developmental biology of uterusine glands.

TL;DR: Results indicate that transient, progestin-induced disruption of ovine uterine development from birth alters both structural and functional integrity of the adult endometrium and limits or inhibits the capacity of uterine tissues to support the establishment and/or maintenance of pregnancy.

TL;DR: It is suggested that a cascade of induction of Mx gene expression proceeds from the luminal epithelium to the outer longitudinal myometrium and that transcriptional activation of the promoter may involve both soluble cytokines and steroid hormones.

TL;DR: This study used endometrium from normal and UGKO sheep to identify messenger RNAs (mRNAs) expressed differentially in the endometrial epithelium using the molecular techniques of mRNA differential display PCR (DD-PCR) and suppression subtractive complementary DNA (cDNA) hybridization (SSH).

TL;DR: In this paper, the effects of specific steroidal agents on patterns of uterine development during defined neonatal periods, as well as the functional consequences of targeted neonatal steroid exposure in the adult uterus, should enable identification of critical developmental mechanisms and determinants of uterus integrity and function.