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Anne Hamacher-Brady
Researcher at Johns Hopkins University
Publications - 43
Citations - 10918
Anne Hamacher-Brady is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Autophagy & Mitochondrion. The author has an hindex of 28, co-authored 42 publications receiving 8860 citations. Previous affiliations of Anne Hamacher-Brady include San Diego State University & German Cancer Research Center.
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Journal ArticleDOI
Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics
Christoph Sebastian Börlin,Christoph Sebastian Börlin,Christoph Sebastian Börlin,Verena Lang,Verena Lang,Anne Hamacher-Brady,Anne Hamacher-Brady,Nathan R. Brady,Nathan R. Brady,Nathan R. Brady +9 more
TL;DR: An agent-based model (ABM) is developed to represent individual components of the autophagy pathway, subcellular vesicle dynamics and metabolic feedback with the cellular environment, thereby providing a framework to investigate spatio-temporal aspects of autophagic regulation and dynamic behavior.
Journal ArticleDOI
Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation.
Paula Andrea Marin Zapata,Carsten Jörn Beese,Anja Jünger,Giovanni Dalmasso,Nathan R. Brady,Nathan R. Brady,Nathan R. Brady,Anne Hamacher-Brady,Anne Hamacher-Brady +8 more
TL;DR: TFEB protein levels and subcellular localization are under control of a short-term rheostat, which is highly responsive to negative regulation by mTOR, but under conditions of mTOR inhibition, restricts TFEB activation in a manner dependent on the proteasome.
Advances in Autophagy
Jiaxiang Shao,Zoltán Giricz,Richard T Williams,Anna Maria Colangelo,Sebastian Wesselborg,Anne Hamacher-Brady +5 more
TL;DR: Three forms of autophagy are commonly described: macroautophagy, microautophagic, and chaperone-mediated autophagosome (CMA), along with mitophagy.
Posted ContentDOI
Listeria monocytogenes virulence factors are secreted in biologically active Extracellular Vesicles
Carolina Coelho,Lisa M. Brown,Maria Maryam,Meagan C. Burnet,Jennifer E. Kyle,Heino M. Heyman,Raghav Vij,Jasmine Ramirez,Rafael Prados-Rosales,Grégoire Lauvau,Ernesto S. Nakayasu,Nathan R. Brady,Anne Hamacher-Brady,Isabelle Coppens,Arturo Casadevall +14 more
TL;DR: It is demonstrated that L. monocytogenes utilize EVs for toxin release and implicate these structures in mammalian cytotoxicity and the deletion of plcA increased EV toxicity, suggesting PI-PLC can restrain LLO activity.
Journal ArticleDOI
CMLS forum reviews: mitochondrial damage control.
TL;DR: The CMLS Forum Reviews as mentioned in this paper present a collection of articles covering select topics on basic mechanisms and pathophysiological contexts of mitochondrial damage control, which can be used to support a functional mitochondrial organelle compartment.