E
Ernesto S. Nakayasu
Researcher at Pacific Northwest National Laboratory
Publications - 166
Citations - 6698
Ernesto S. Nakayasu is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 40, co-authored 146 publications receiving 5374 citations. Previous affiliations of Ernesto S. Nakayasu include University of Texas at El Paso & Bruker.
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Journal ArticleDOI
Activated ClpP kills persisters and eradicates a chronic biofilm infection
Brian P. Conlon,Ernesto S. Nakayasu,Ernesto S. Nakayasu,Laura E. Fleck,Michael D. LaFleur,Vincent M. Isabella,Ken Coleman,Steven N. Leonard,Richard D. Smith,Joshua N. Adkins,Kim Lewis +10 more
TL;DR: It is shown that ADEP4-activated ClpP becomes a fairly nonspecific protease and kills persisters by degrading over 400 proteins, forcing cells to self-digest, indicating a general principle for killing dormant cells—activation and corruption of a target, rather than conventional inhibition.
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Extracellular Vesicles Produced by Cryptococcus neoformans Contain Protein Components Associated with Virulence
Marcio L. Rodrigues,Ernesto S. Nakayasu,Débora L. Oliveira,Leonardo Nimrichter,Joshua D. Nosanchuk,Igor C. Almeida,Arturo Casadevall +6 more
TL;DR: An efficient and general mechanism of secretion of pathogenesis-related molecules in C. neoformans is revealed, suggesting that extracellular vesicles function as “virulence bags” that deliver a concentrated payload of fungal products to host effector cells and tissues.
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Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes
Priscila C. Albuquerque,Ernesto S. Nakayasu,Marcio L. Rodrigues,Susana Frases,Arturo Casadevall,Rosely Maria Zancopé-Oliveira,Igor C. Almeida,Joshua D. Nosanchuk +7 more
TL;DR: The results demonstrate that H. capsulatum can utilize a trans‐cell wall vesicular transport secretory mechanism to promote virulence and support the proposal that vesicle secretion is a general mechanism in fungi for the transport of macromolecules related to virulence.
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Ubiquitination independent of E1 and E2 enzymes by bacterial effectors
Jiazhang Qiu,Michael J. Sheedlo,Kaiwen Yu,Yunhao Tan,Ernesto S. Nakayasu,Chittaranjan Das,Xiaoyun Liu,Zhao-Qing Luo +7 more
TL;DR: It is established that ubiquitination can be catalysed by a single enzyme, the activity of which does not require ATP.
Journal ArticleDOI
Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis.
Débora L. Oliveira,Ernesto S. Nakayasu,Ernesto S. Nakayasu,Luna S. Joffe,Allan J. Guimarães,Tiago J. P. Sobreira,Joshua D. Nosanchuk,Radames J. B. Cordero,Susana Frases,Arturo Casadevall,Igor C. Almeida,Leonardo Nimrichter,Marcio L. Rodrigues +12 more
TL;DR: The results suggest that both conventional and unconventional pathways of secretion are required for biogenesis of extracellular vesicles, which demonstrate the complexity of this process in the biology of yeast cells.