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Anne Quesnel-Hellmann
Publications - 17
Citations - 711
Anne Quesnel-Hellmann is an academic researcher. The author has contributed to research in topics: Bacillus anthracis & Immune system. The author has an hindex of 10, co-authored 17 publications receiving 697 citations.
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Journal ArticleDOI
Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route.
Aurélie Cleret,Anne Quesnel-Hellmann,Alexandra Vallon-Eberhard,Alexandra Vallon-Eberhard,Bernard Verrier,Steffen Jung,Dominique R. Vidal,Jacques Mathieu,Jean-Nicolas Tournier +8 more
TL;DR: It is shown that interstitial LDCs constitute the cell population that transports spores into the thoracic lymph nodes from within 30 min to 72 h after intranasal infection and are central to spore transport immediately after infection.
Journal ArticleDOI
Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells.
Jean-Nicolas Tournier,Anne Quesnel-Hellmann,Jacques Mathieu,Cesare Montecucco,Wei-Jen Tang,Michèle Mock,Dominique R. Vidal,Pierre L. Goossens +7 more
TL;DR: It is suggested that ET produced during infection impairs DC functions and cooperates with LT to suppress the innate immune response, which may represent a new strategy developed by B. anthracis to escape the host immune response.
Journal ArticleDOI
Anthrax toxins: A weapon to systematically dismantle the host immune defenses
TL;DR: The specific effects of the lethal and edema toxins of B. anthracis on the activation and function of phagocytes, dendritic cells and lymphocytes are reviewed.
Journal ArticleDOI
Contribution of toxins to the pathogenesis of inhalational anthrax.
TL;DR: In this paper, the authors describe three major steps in infection: (i) an invasion phase in the lung, during which toxins have short-distance effects on lung phagocytes; (ii) a phase of bacillus proliferation in the mediastinal lymph nodes, with local effects of toxins; and (iii) a terminal, diffusion phase, characterized by a high blood bacterial load and by long distance effects of poisons, leading to host death.
Journal ArticleDOI
Resident CD11c+ Lung Cells Are Impaired by Anthrax Toxins after Spore Infection
Aurélie Cleret,Anne Quesnel-Hellmann,Jacques Mathieu,Dominique R. Vidal,Jean-Nicolas Tournier +4 more
TL;DR: It is suggested that anthrax toxins secreted during infection impair LDC function and suppress the innate immune response and appear to impair the ability of the immune system to defend against anthrax.