W
Wei-Jen Tang
Researcher at University of Chicago
Publications - 147
Citations - 10391
Wei-Jen Tang is an academic researcher from University of Chicago. The author has contributed to research in topics: Adenylyl cyclase & ADCY10. The author has an hindex of 53, co-authored 130 publications receiving 9780 citations. Previous affiliations of Wei-Jen Tang include University of Texas Southwestern Medical Center & University of Missouri.
Papers
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Journal ArticleDOI
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Wei-Jen Tang,Alfred G. Gilman +1 more
TL;DR: G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase, and interactions suggest mechanisms for communication between distinct signal-transducing pathways.
Journal ArticleDOI
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure.
John Krupinski,Françoise Coussen,Françoise Coussen,Heather A. Bakalyar,Wei-Jen Tang,Paul Feinstein,Kim Orth,Clive A. Slaughter,Randall R. Reed,Alfred G. Gilman +9 more
TL;DR: An unexpected topographical resemblance between adenylyl cyclase and various plasma membrane channels and transporters was observed, which suggests possible, unappreciated functions for this important enzyme.
Journal ArticleDOI
Expression and characterization of calmodulin-activated (type I) adenylylcyclase
TL;DR: A complementary DNA that encodes a bovine brain, calmodulin-sensitive (type I) adenylylcyclase has been inserted into the baculovirus genome under the control of the strong polyhedron promoter.
Journal ArticleDOI
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Chester L. Drum,Shui-Zhong Yan,Joel Bard,Yuequan Shen,Dan Lu,Sandriyana Soelaiman,Zenon Grabarek,Andrew Bohm,Andrew Bohm,Wei-Jen Tang +9 more
TL;DR: Allosteric changes of oedema factor provide the first molecular details of how calmodulin modulates one of its targets.
Journal ArticleDOI
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
TL;DR: Examination of the effects of native and mutant Gi alpha proteins, as well as analysis of competition for binding of Gs alpha to adenylyl cyclases, indicate that at least certain adenyll cyclases have independent sites for interaction with Gsalpha and Gi alpha.