A
Anne Wojtusciszyn
Researcher at University of Lausanne
Publications - 73
Citations - 1780
Anne Wojtusciszyn is an academic researcher from University of Lausanne. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 20, co-authored 59 publications receiving 1401 citations. Previous affiliations of Anne Wojtusciszyn include Geneva College & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4
Elodie M. Varin,Elodie M. Varin,Anne Wojtusciszyn,Anne Wojtusciszyn,Christophe Broca,Dany Muller,Magalie A. Ravier,Franck Ceppo,Eric Renard,Eric Renard,J-F Tanti,Stéphane Dalle,Stéphane Dalle +12 more
TL;DR: It is proposed that Tpl2 inhibitors, used either alone or combined with a GLP-1 analog, represent potential novel and effective therapeutic strategies to protect diabetic β-cells.
Journal ArticleDOI
Pancreas preservation fluid microbial contamination is associated with poor islet isolation outcomes - a multi-centre cohort study.
Raphael P. H. Meier,Raphael P. H. Meier,Diego O. Andrey,Pamela Sun,Nadja Niclauss,Benoît Bédat,Sandrine Demuylder-Mischler,Sophie Borot,Pierre-Yves Benhamou,Anne Wojtusciszyn,Fanny Buron,Nadine Pernin,Yannick D. Muller,Domenico Bosco,Christian van Delden,Thierry Berney +15 more
TL;DR: Pancreas preservation fluid microbial contamination is associated with lower transplant rate and poorer in vitro function, but not with changes in graft survival, and culture medium testing 1 day after isolation reduces the risk of incidental transplantation with contaminated islets.
Journal ArticleDOI
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment
Lucie Ruiz,Tatyana Gurlo,Magalie A. Ravier,Anne Wojtusciszyn,Julia Mathieu,Matthew R. Brown,Christophe Broca,Gyslaine Bertrand,Peter C. Butler,Aleksey V. Matveyenko,Stéphane Dalle,Safia Costes +11 more
TL;DR: It is found that proteasomal degradation is the mechanism subserving p300 loss in beta-cells exposed to hyperglycemia or pro-inflammatory cytokines, and that melatonin, a hormone produced in the pineal gland and known to play key roles in Beta-cell health, preserves p300 levels altered by these toxic conditions.
Journal ArticleDOI
Assessment of 18F-FDG-leukocyte imaging to monitor rejection after pancreatic islet transplantation.
Christian Toso,Habib Zaidi,Philippe Morel,Mathieu Pierre Jean Armanet,Anne Wojtusciszyn,Gang Mai,Reto M. Baertschiger,Leo Buhler,Thierry Berney +8 more
TL;DR: The liver showed a relatively high spontaneous tracer uptake and Liver FDG uptake was similar between syngeneic, allogeneic, and sensitized allogenic groups at 4 and 7 days after islet transplantation.
Journal ArticleDOI
A comparison of cold storage solutions for pancreas preservation prior to islet isolation.
Anne Wojtusciszyn,Domenico Bosco,Philippe Morel,Reto M. Baertschiger,Mathieu Pierre Jean Armanet,Marie-Claude Kempf,Lionel Badet,Christian Toso,Thierry Berney +8 more
TL;DR: In this preliminary study, UW, Celsior, and IGL-1 solutions demonstrated similar islet isolation results and the new I GL-1 solution appears promising.