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Annelies Janssens
Researcher at Katholieke Universiteit Leuven
Publications - 116
Citations - 6832
Annelies Janssens is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 31, co-authored 84 publications receiving 5945 citations. Previous affiliations of Annelies Janssens include The Catholic University of America & Catholic University of Leuven.
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Journal ArticleDOI
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
TL;DR: Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Journal ArticleDOI
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.
Joris Vriens,Hiroyuki Watanabe,Annelies Janssens,Guillaume Droogmans,Thomas Voets,Bernd Nilius +5 more
TL;DR: It is demonstrated that blockers of phospholipase A2 (PLA2) and cytochrome P450 epoxygenase inhibit activation of TRPV4 by osmotic cell swelling but not by heat and 4α-phorbol 12,13-didecanoate, and it is concluded that TRpV4-activating stimuli promote channel opening by means of distinct pathways.
Journal ArticleDOI
TRPA1 acts as a cold sensor in vitro and in vivo
Yuji Karashima,Karel Talavera,Wouter Everaerts,Annelies Janssens,Kelvin Y. Kwan,Rudi Vennekens,Bernd Nilius,Thomas Voets +7 more
TL;DR: It is concluded that TRPA1 acts as a major sensor for noxious cold, and a specific subset of cold-sensitive trigeminal ganglion neurons that is absent inTRPA1-deficient mice are identified.
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TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat
Joris Vriens,Grzegorz Owsianik,Thomas Hofmann,Stephan E. Philipp,Julia Stab,Xiaodi Chen,Melissa Benoit,Fenqin Xue,Annelies Janssens,Sara Kerselaers,Johannes Oberwinkler,Rudi Vennekens,Thomas Gudermann,Bernd Nilius,Thomas Voets +14 more
TL;DR: Evidence is provided that TRPM3 functions as a chemo- and thermosensor in the somatosensory system and an unanticipated role for TR PM3 as a thermosensitive nociceptor channel implicated in the detection of noxious heat is revealed.
Journal ArticleDOI
Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium
Joris Vriens,Grzegorz Owsianik,Beate Fisslthaler,M Suzuki,Annelies Janssens,Thomas Voets,Christophe Morisseau,Bruce D. Hammock,Ingrid Fleming,Rudi Busse,Bernd Nilius +10 more
TL;DR: It is established that CYP-derived EETs modulate the activity of TRPV4 channels in endothelial cells and shows the unraveling of novel modulatory pathways via CYP2C modulation and sEH inhibition.