T
Thomas Voets
Researcher at Katholieke Universiteit Leuven
Publications - 269
Citations - 26082
Thomas Voets is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Transient receptor potential channel & TRPV1. The author has an hindex of 82, co-authored 254 publications receiving 23653 citations. Previous affiliations of Thomas Voets include The Catholic University of America & Saarland University.
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Journal ArticleDOI
Transient Receptor Potential Cation Channels in Disease
TL;DR: An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
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The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels
TL;DR: Kinetic analysis of gating at different temperatures indicates that temperature sensitivity in TRPM8 and TRPV1 arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
TL;DR: It is shown that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of epoxyeicosatrienoic acids.
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Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.
Joris Vriens,Hiroyuki Watanabe,Annelies Janssens,Guillaume Droogmans,Thomas Voets,Bernd Nilius +5 more
TL;DR: It is demonstrated that blockers of phospholipase A2 (PLA2) and cytochrome P450 epoxygenase inhibit activation of TRPV4 by osmotic cell swelling but not by heat and 4α-phorbol 12,13-didecanoate, and it is concluded that TRpV4-activating stimuli promote channel opening by means of distinct pathways.
Journal ArticleDOI
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption.
Thomas Voets,Bernd Nilius,Susan Hoefs,Annemiete W.C.M. van der Kemp,Guy Droogmans,René J. M. Bindels,Joost G. J. Hoenderop +6 more
TL;DR: It is shown that TRPM6 is specifically localized along the apical membrane of the renal distal convoluted tubule and the brush-border membranes of the small intestine, epithelia particularly associated with active Mg2+ (re)absorption.