A
Annemarie E. Brouwer
Researcher at Radboud University Nijmegen
Publications - 29
Citations - 2204
Annemarie E. Brouwer is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Meningitis & Cryptococcosis. The author has an hindex of 16, co-authored 28 publications receiving 1994 citations. Previous affiliations of Annemarie E. Brouwer include St George's, University of London & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial
Annemarie E. Brouwer,Adul Rajanuwong,Wirongrong Chierakul,George E. Griffin,Robert A. Larsen,Nicholas J. White,Nicholas J. White,Thomas S. Harrison +7 more
TL;DR: Quantification of CSF cultures provides a powerful new means to accurately assess the fungicidal activity of new treatment regimens for cryptococcal meningitis.
Journal ArticleDOI
Determinants of Mortality in a Combined Cohort of 501 Patients With HIV-Associated Cryptococcal Meningitis: Implications for Improving Outcomes
Joseph N Jarvis,Tihana Bicanic,Angela Loyse,Daniel Namarika,Arthur Jackson,Jesse C. Nussbaum,Jesse C. Nussbaum,Nicky Longley,Nicky Longley,Conrad Muzoora,Jacob Phulusa,Kabanda Taseera,Creto Kanyembe,Douglas Wilson,Mina C. Hosseinipour,Annemarie E. Brouwer,Direk Limmathurotsakul,Nicholas J. White,Nicholas J. White,Charles van der Horst,Robin Wood,Graeme Meintjes,Graeme Meintjes,John S. Bradley,Shabbar Jaffar,Thomas S. Harrison +25 more
TL;DR: Cerebrospinal fluid fungal burden, altered mental status, and rate of clearance of infection predict acute mortality in HIV-associated cryptococcal meningitis.
Journal ArticleDOI
High-Dose Amphotericin B with Flucytosine for the Treatment of Cryptococcal Meningitis in HIV-Infected Patients: A Randomized Trial.
Tihana Bicanic,Robin Wood,Graeme Meintjes,Kevin Rebe,Annemarie E. Brouwer,Angela Loyse,Linda-Gail Bekker,Shabbar Jaffar,Thomas S. Harrison +8 more
TL;DR: AmB, 1 mg/kg per day, plus flucytosine is more rapidly fungicidal than is standard-dose AmB plus fluconazole, and toxicities were manageable and reversible.
Journal ArticleDOI
Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV-Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients
Tihana Bicanic,Conrad Muzoora,Annemarie E. Brouwer,Graeme Meintjes,Nicky Longley,Kabanda Taseera,Kevin Rebe,Angela Loyse,Joseph N Jarvis,Linda-Gail Bekker,Robin Wood,Direk Limmathurotsakul,Wirongrong Chierakul,Kasia Stepniewska,Kasia Stepniewska,Nicholas J. White,Nicholas J. White,Shabbar Jaffar,Thomas S. Harrison +18 more
TL;DR: The results support the use of the rate of clearance of infection or early fungicidal activity as a means to explore antifungal drug dosages and combinations in phase II studies.
Journal ArticleDOI
Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures.
Tihana Bicanic,Annemarie E. Brouwer,Graeme Meintjes,Kevin Rebe,Direk Limmathurotsakul,Wirongrong Chierakul,Praprit Teparrakkul,Angela Loyse,Nicholas J. White,Robin Wood,Shabbar Jaffar,Tom Harrison +11 more
TL;DR: The results support increasing access to manometers in resource-poor settings and routine management of opening pressure in patients with cryptococcal meningitis.