A
Angela Loyse
Researcher at St George's, University of London
Publications - 59
Citations - 4636
Angela Loyse is an academic researcher from St George's, University of London. The author has contributed to research in topics: Meningitis & Flucytosine. The author has an hindex of 24, co-authored 54 publications receiving 3510 citations. Previous affiliations of Angela Loyse include Pasteur Institute & University of London.
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Journal ArticleDOI
Global burden of disease of HIV-associated cryptococcal meningitis: An updated analysis
Radha Rajasingham,Rachel M. Smith,Benjamin J. Park,Joseph N Jarvis,Nelesh P. Govender,Nelesh P. Govender,Nelesh P. Govender,Tom Chiller,David W. Denning,Angela Loyse,David R. Boulware +10 more
TL;DR: The analysis highlights the substantial ongoing burden of HIV-associated cryptococcal disease, primarily in sub-Saharan Africa, which is a metric of HIV treatment programme failure; timely HIV testing and rapid linkage to care remain an urgent priority.
Journal ArticleDOI
Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy.
Peter R. Williamson,Joseph N Jarvis,Anil A. Panackal,Matthew C. Fisher,Síle F. Molloy,Angela Loyse,Thomas S. Harrison +6 more
TL;DR: Protective immune responses in HIV-associated cases, immunogenetic predisposition to infection, and the role of immune-mediated pathology in patients with non-HIV associated infection and in the context of HIV- associated immune reconstitution reactions are better understood.
Journal ArticleDOI
Determinants of Mortality in a Combined Cohort of 501 Patients With HIV-Associated Cryptococcal Meningitis: Implications for Improving Outcomes
Joseph N Jarvis,Tihana Bicanic,Angela Loyse,Daniel Namarika,Arthur Jackson,Jesse C. Nussbaum,Jesse C. Nussbaum,Nicky Longley,Nicky Longley,Conrad Muzoora,Jacob Phulusa,Kabanda Taseera,Creto Kanyembe,Douglas Wilson,Mina C. Hosseinipour,Annemarie E. Brouwer,Direk Limmathurotsakul,Nicholas J. White,Nicholas J. White,Charles van der Horst,Robin Wood,Graeme Meintjes,Graeme Meintjes,John S. Bradley,Shabbar Jaffar,Thomas S. Harrison +25 more
TL;DR: Cerebrospinal fluid fungal burden, altered mental status, and rate of clearance of infection predict acute mortality in HIV-associated cryptococcal meningitis.
Journal ArticleDOI
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa
Síle F. Molloy,Cecilia Kanyama,Robert S. Heyderman,Angela Loyse,Charles Kouanfack,Duncan Chanda,Sayoki Mfinanga,Elvis Temfack,Shabir Lakhi,Sokoine Lesikari,Adrienne K. Chan,Neil Stone,Newton Kalata,Natasha Karunaharan,Katherine M Gaskell,Mary Peirse,Jayne Ellis,Chimwemwe Chawinga,Sandrine Lontsi,Jean-Gilbert Ndong,Philip Bright,Duncan Lupiya,Tao Chen,John S. Bradley,Jack Adams,Charles van der Horst,Joep J. van Oosterhout,Victor Sini,Yacouba Mapoure,Peter Mwaba,Tihana Bicanic,David G. Lalloo,Duolao Wang,Mina C. Hosseinipour,Olivier Lortholary,Shabbar Jaffar,Tom Harrison +36 more
TL;DR: Two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy were tested.
Journal ArticleDOI
High-Dose Amphotericin B with Flucytosine for the Treatment of Cryptococcal Meningitis in HIV-Infected Patients: A Randomized Trial.
Tihana Bicanic,Robin Wood,Graeme Meintjes,Kevin Rebe,Annemarie E. Brouwer,Angela Loyse,Linda-Gail Bekker,Shabbar Jaffar,Thomas S. Harrison +8 more
TL;DR: AmB, 1 mg/kg per day, plus flucytosine is more rapidly fungicidal than is standard-dose AmB plus fluconazole, and toxicities were manageable and reversible.