J
Jesse C. Nussbaum
Researcher at University of California, San Francisco
Publications - 21
Citations - 4538
Jesse C. Nussbaum is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Innate lymphoid cell & Inflammation. The author has an hindex of 16, co-authored 20 publications receiving 3767 citations. Previous affiliations of Jesse C. Nussbaum include University of North Carolina at Chapel Hill & Merck & Co..
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Journal ArticleDOI
Type 2 innate lymphoid cells control eosinophil homeostasis
Jesse C. Nussbaum,Steven J. Van Dyken,Jakob von Moltke,Laurence E. Cheng,Alexander Mohapatra,Ari B. Molofsky,Emily E. Thornton,Matthew F. Krummel,Ajay Chawla,Hong-Erh Liang,Richard M. Locksley +10 more
TL;DR: It is shown that serum IL-5 levels are maintained by long-lived type 2 innate lymphoid cells (ILC2) resident in peripheral tissues, and this dissociated regulation can be tuned by nutrient intake and central circadian rhythms.
Journal ArticleDOI
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
Ari B. Molofsky,Jesse C. Nussbaum,Hong-Erh Liang,Steven J. Van Dyken,Laurence E. Cheng,Alexander Mohapatra,Ajay Chawla,Richard M. Locksley +7 more
TL;DR: Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.
Journal ArticleDOI
Activated type 2 innate lymphoid cells regulate beige fat biogenesis
Min Woo Lee,Justin I. Odegaard,Lata Mukundan,Yifu Qiu,Ari B. Molofsky,Jesse C. Nussbaum,Karen Yun,Richard M. Locksley,Ajay Chawla +8 more
TL;DR: It is reported here that activation of ILC2s by IL-33 is sufficient to promote the growth of functional beige fat in thermoneutral mice and highlights a critical role for I LC2s and type 2 cytokines in the regulation of adipocyte precursor numbers and fate, and as a consequence, adipose tissue homeostasis.
Journal ArticleDOI
InterleuKin-33 And Interferon-Γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation During Immune Perturbation
Ari B. Molofsky,Frédéric Van Gool,Hong-Erh Liang,Steven J. Van Dyken,Jesse C. Nussbaum,Jinwoo Lee,Jeffrey A. Bluestone,Richard M. Locksley +7 more
TL;DR: Interleukin-33 mediates activation of ILC2s and Treg cells in resting adipose tissue, but also after helminth infection or treatment with IL-2, and IFN-γ suppresses this pathway, likely to promote inflammatory responses and divert metabolic resources necessary to protect the host.
Journal ArticleDOI
Tissue signals imprint ILC2 identity with anticipatory function.
Roberto R. Ricardo-Gonzalez,Steven J. Van Dyken,Steven J. Van Dyken,Christoph Schneider,Jinwoo Lee,Jesse C. Nussbaum,Hong-Erh Liang,Dedeepya Vaka,Walter L. Eckalbar,Ari B. Molofsky,David J. Erle,Richard M. Locksley +11 more
TL;DR: Tissue-specific imprinting dictates the activating receptors ILC2s express, even in germ-free mice, and it is shown that endogenous, tissue-derived signals drive the maturation of I LC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.