A
Anning Lin
Researcher at University of Chicago
Publications - 71
Citations - 15555
Anning Lin is an academic researcher from University of Chicago. The author has contributed to research in topics: Protein kinase A & MAP kinase kinase kinase. The author has an hindex of 43, co-authored 69 publications receiving 15049 citations. Previous affiliations of Anning Lin include Nanjing University & Guangzhou Medical University.
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Journal ArticleDOI
NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
TL;DR: This work has identified a serine/threonine kinase whose activity is stimulated by the same signals that stimulate the amino-terminal phosphorylation of c-Jun, and suggests a mechanism through which protein kinase cascades can specifically modulate the activity of distinct nuclear targets.
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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
TL;DR: Results with dominant interfering alleles place Rac1 as an intermediate between Ha-Ras and MEKK in the signaling cascade leading from growth factor receptors and v-Src to JNK activation.
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Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
Audrey Minden,Anning Lin,Martin McMahon,Carol A. Lange-Carter,Benoit Dérijard,Roger J. Davis,Gary L. Johnson,Michael Karin +7 more
TL;DR: These results demonstrate the existence of two distinct Ras-dependent MAPK cascades--one initiated by Raf-1 leading to ERK activation, and the other initiated by MEKK leading to JNK activation.
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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
Anning Lin,Audrey Minden,Horacio Martinetto,Francois Xavier Claret,Carol A. Lange-Carter,Frank Mercurio,Gary L. Johnson,Michael Karin +7 more
TL;DR: A dual-specificity kinase that activates JNK, named JNKK, was identified that functions between MEKK and JNK and was unresponsive to Raf-1 in transfected HeLa cells.