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Anthony M. Buckley
Researcher at University of Leeds
Publications - 39
Citations - 1663
Anthony M. Buckley is an academic researcher from University of Leeds. The author has contributed to research in topics: Clostridium difficile & Salmonella enterica. The author has an hindex of 18, co-authored 35 publications receiving 1367 citations. Previous affiliations of Anthony M. Buckley include University of Glasgow & University of Birmingham.
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Journal ArticleDOI
The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis.
Anthony M. Buckley,Mark A. Webber,S. W. Cooles,Luke P. Randall,Roberto M. La Ragione,Martin J. Woodward,Laura J. V. Piddock +6 more
TL;DR: Data indicate that the AcrAB–TolC system is important for the colonization of chickens by S. Typhimurium and that this system has a role in mediating adherence and uptake into target host cells.
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Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.
Roy R. Chaudhuri,Eirwen Morgan,Sarah Peters,Stephen J. Pleasance,Debra L. Hudson,Holly Davies,Jinhong Wang,Pauline M. van Diemen,Anthony M. Buckley,Alison J. Bowen,Gillian D. Pullinger,Daniel J. Turner,Gemma C. Langridge,A. Keith Turner,Julian Parkhill,Ian G. Charles,Duncan J. Maskell,Mark P. Stevens +17 more
TL;DR: By simultaneously assigning the genotype and phenotype of over 90% of mutants screened in complex pools by transposon-directed insertion-site sequencing, the data establish TraDIS as a powerful tool to apply rich functional annotation to microbial genomes with minimal animal use.
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Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo
Janet Y. Nale,Janice Spencer,Katherine R. Hargreaves,Anthony M. Buckley,Przemysław Trzepiński,Gillian Douce,Martha R. J. Clokie +6 more
TL;DR: Detailed host range analysis of six myoviruses and one siphovirus was conducted on 80 strains representing 21 major epidemic and clinically severe ribotypes, demonstrating the therapeutic potential of phage combinations to treat CDI.
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The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile
Glen P. Carter,Gillian Douce,Revathi Govind,Pauline Howarth,Kate E. Mackin,Janice Spencer,Anthony M. Buckley,Ana Antunes,Despina Kotsanas,Grant A. Jenkin,Bruno Dupuy,Julian I. Rood,Dena Lyras +12 more
TL;DR: Evidence is provided that a naturally occurring mutation in a negative regulator of toxin production, the anti-sigma factor TcdC, is an important factor in the development of hypervirulence in epidemic C. difficile isolates, presumably because the mutation leads to significantly increased toxin production.
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Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC
TL;DR: Functional AcrB and TolC in S. enterica serovar Typhimurium are important for the selection of ciprofloxacin-resistant mutants.