D
Duncan J. Maskell
Researcher at University of Cambridge
Publications - 232
Citations - 16599
Duncan J. Maskell is an academic researcher from University of Cambridge. The author has contributed to research in topics: Salmonella enterica & Salmonella. The author has an hindex of 64, co-authored 230 publications receiving 15350 citations. Previous affiliations of Duncan J. Maskell include University of Oxford & Imperial College London.
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Journal ArticleDOI
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Julian Parkhill,Mohammed Sebaihia,Andrew Preston,Lee Murphy,Nicholas R. Thomson,David Harris,Matthew T. G. Holden,Carol Churcher,Stephen D. Bentley,Karen Mungall,Ana Cerdeño-Tárraga,Louise M. Temple,Keith D. James,Barbara Harris,Michael A. Quail,Mark Achtman,Rebecca Atkin,Steven K. Baker,David Basham,Nathalie Bason,Inna Cherevach,Tracey Chillingworth,Matthew Collins,Anne Cronin,Paul Davis,Jonathan Doggett,Theresa Feltwell,Arlette Goble,N. Hamlin,Heidi Hauser,S. Holroyd,Kay Jagels,Sampsa Leather,Sharon Moule,Halina Norberczak,Susan O'Neil,Doug Ormond,Claire Price,Ester Rabbinowitsch,Simon Rutter,Mandy Sanders,David L. Saunders,Katherine Seeger,Sarah Sharp,Mark Simmonds,Jason Skelton,R. Squares,S. Squares,K. Stevens,Louise Unwin,Sally Whitehead,Bart Barrell,Duncan J. Maskell +52 more
TL;DR: The authors' analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.
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Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Laura García-Álvarez,Matthew T. G. Holden,Heather Lindsay,Cerian R. Webb,Derek F. J. Brown,Martin D. Curran,Enid Walpole,Karen Brooks,Derek Pickard,Christopher Teale,Julian Parkhill,Stephen D. Bentley,Giles Edwards,E Kirsty Girvan,Angela M. Kearns,Bruno Pichon,Robert Hill,Anders Rhod Larsen,Robert Skov,Sharon J. Peacock,Duncan J. Maskell,Mark A. Holmes +21 more
TL;DR: The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251.
Journal ArticleDOI
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants
Gemma C. Langridge,Minh-Duy Phan,Daniel J. Turner,Tim Perkins,Leopold Parts,Jana K. Haase,Ian G. Charles,Duncan J. Maskell,Sarah Peters,Gordon Dougan,John Wain,Julian Parkhill,A. Keith Turner +12 more
TL;DR: This screen validated the hypothesis that the authors can simultaneously assay every gene in the genome to identify niche-specific essential genes and generate a genome-wide list of candidate essential genes.
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Bacterial polysaccharide synthesis and gene nomenclature
Peter R. Reeves,Matthew Hobbs,Miguel A. Valvano,Mikael Skurnik,Chris Whitfield,David L. Coplin,Nobuo Kido,John D. Klena,Duncan J. Maskell,Christian R. H. Raetz,Paul D. Rick +10 more
TL;DR: This work proposes a scheme applicable to all species that distinguishes different classes of genes, provides a single name for all genes of a given function and greatly facilitates comparative studies.
Journal ArticleDOI
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Kathryn E. Holt,Julian Parkhill,Camila J. Mazzoni,Philippe Roumagnac,François-Xavier Weill,Ian Goodhead,Ian Goodhead,Richard Rance,Stephen Baker,Stephen Baker,Duncan J. Maskell,John Wain,Christiane Dolecek,Mark Achtman,Gordon Dougan +14 more
TL;DR: The observed patterns of genetic isolation and drift are consistent with the proposed key role of asymptomatic carriers of Typhi as the main reservoir of this pathogen, highlighting the need for identification and treatment of carriers.