L
Laura J. V. Piddock
Researcher at University of Birmingham
Publications - 290
Citations - 29810
Laura J. V. Piddock is an academic researcher from University of Birmingham. The author has contributed to research in topics: Efflux & Antibacterial agent. The author has an hindex of 78, co-authored 281 publications receiving 24965 citations. Previous affiliations of Laura J. V. Piddock include British Society for Antimicrobial Chemotherapy & Drugs for Neglected Diseases Initiative.
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Journal ArticleDOI
Molecular mechanisms of antibiotic resistance.
TL;DR: Recent advances in understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics are reviewed, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.
Journal ArticleDOI
The Comprehensive Antibiotic Resistance Database
Andrew G. McArthur,Nicholas Waglechner,Fazmin Nizam,Austin Yan,Marisa A. Azad,Alison J. Baylay,Kirandeep Bhullar,Marc J. Canova,Gianfranco De Pascale,Linda Ejim,Lindsay Kalan,Andrew M. King,Kalinka Koteva,Mariya Morar,Michael R. Mulvey,Jonathan S O'Brien,Andrew C. Pawlowski,Laura J. V. Piddock,Peter Spanogiannopoulos,Arlene D. Sutherland,Irene Tang,Patricia L. Taylor,Maulik N. Thaker,Wenliang Wang,Marie Yan,Tennison Yu,Gerard D. Wright +26 more
TL;DR: The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences.
Journal ArticleDOI
Understanding the mechanisms and drivers of antimicrobial resistance
Alison Holmes,Luke S. P. Moore,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Martin Steinbakk,Sadie Regmi,Abhilasha Karkey,Philippe J Guerin,Laura J. V. Piddock +8 more
TL;DR: In this paper, the authors proposed a framework to combat the threat to human health and biosecurity from antimicrobial resistance, an understanding of its mechanisms and drivers is needed.
Journal ArticleDOI
Multidrug-resistance efflux pumps ? not just for resistance
TL;DR: Evidence is presented that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and it is proposed that these pumps therefore have greater clinical relevance than is usually attributed to them.
Antimicrobials: access and sustainable eff ectiveness 2 Understanding the mechanisms and drivers of antimicrobial resistance
Alison Holmes,Luke Sp Moore,Martin Steinbakk,Sadie Regmi,Philippe J Guerin,Laura J. V. Piddock +5 more
TL;DR: To combat the threat to human health and biosecurity from antimicrobial resistance, an understanding of its mechanisms and drivers is needed, and broad ranging, multidisciplinary research is needed across these five levels.