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Anthony P. Corfield
Researcher at Bristol Royal Infirmary
Publications - 132
Citations - 5974
Anthony P. Corfield is an academic researcher from Bristol Royal Infirmary. The author has contributed to research in topics: Mucin & Mucus. The author has an hindex of 41, co-authored 132 publications receiving 5599 citations.
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Mucins: A biologically relevant glycan barrier in mucosal protection
TL;DR: Mucin biology is dynamic and the processes of degradation and turnover are well integrated with biosynthesis to maintain a continuous mucosal protection against all external aggressive forces.
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Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease
TL;DR: Improvements in analytical techniques coupled with detailed knowledge of the genes coding for the mucin proteins have provided exciting new insights into the role of the mucous layer and its relevance to gastrointestinal disease.
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Mucins in the gastrointestinal tract in health and disease.
TL;DR: Review of the major mucosal diseases affecting the gastrointestinal tract in childhood reveals parallel patterns to those found in adult pathology, but with some novel conditions arising through the developmental stages at lactation and weaning.
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Mucins and inflammatory bowel disease
TL;DR: There seem to be differences in the expression of trefoils in the colon and the small bowel, which may imply different method of mucosal repair, and these changes can alter the function of the mucins.
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Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria.
TL;DR: It is concluded that the presence of two or more O-acetyl groups on sialic acids inhibits enteric bacterial sialidases but that production of sialate O-acetylesterases by several populations of enteric bacteria lessens the likelihood that mucin oligosaccharide chains terminating in O- acetylated sIALic acids are protected from degradation.