Anthony P. Corfield

TL;DR: AFM analysis of mucin polymers at the single molecule level provides new information about the genetic origins of individual polymers and the contributions of glycosylation to the physicochemical properties of mucins, which can be correlated with information obtained from biochemistry, antibody binding assays, and molecular biology techniques.

TL;DR: Analysis of the glycopolypeptide amino acids obtained from 24 control and 13 UC patients showed a close correlation with the predicted ratio of serine threonine and proline expected for the MUC2 tandem repeat, as well as a significant reduction in the ratio between control and UC groups.

TL;DR: It is shown that normal canine ocular mucus contains two secreted mucins, each exhibiting different subunit structure; one of these mucins may undergo lipid complexation.

TL;DR: The data demonstrate the presence of mono-O-Acetylated sialic acids in normal canine ocular mucins and a loss of this population of sialing acids in dry eye disease in spite of a significant increase in total siali acids in KCS mucin.

TL;DR: The identification of unusual partially glycosylated forms of the major colonic mucin MUC2 is novel and unexpected and opens a new field in the cancer mucin biology.