A
Anthony P. Corfield
Researcher at Bristol Royal Infirmary
Publications - 132
Citations - 5974
Anthony P. Corfield is an academic researcher from Bristol Royal Infirmary. The author has contributed to research in topics: Mucin & Mucus. The author has an hindex of 41, co-authored 132 publications receiving 5599 citations.
Papers
More filters
Journal ArticleDOI
Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units
John K. Sheehan,David J. Thornton,Marj Howard,Ingemar Carlstedt,Anthony P. Corfield,Christos Paraskeva +5 more
TL;DR: The human colonic cell line PC/AA was grown to near confluency over 24 days and labelled with [14C]proline and [3H]glucose over the last 48 h in culture and the mature fully glycosylated mucins were identified as MUC2 with an anti-peptide antibody.
Journal ArticleDOI
Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma.
Udo Roth,Hanieh Razawi,Julia Hommer,Katja Engelmann,Tilo Schwientek,Stefan Müller,Stephan Baldus,Georgios Patsos,Anthony P. Corfield,Christos Paraskeva,Franz-Georg Hanisch +10 more
TL;DR: This is the first differential expression proteomics study on a human syngeneic cellular in vitro progression model of the colorectal adenoma‐to‐carcinoma sequence and 13 proteins were revealed as regulated with statistical variance being within the 95th confidence level.
Journal ArticleDOI
Degradation by bacterial enzymes of colonic mucus from normal subjects and patients with inflammatory bowel disease: the role of sialic acid metabolism and the detection of a novel O-acetylsialic acid esterase.
Anthony P. Corfield,Andrew J. K. Williams,John R. Clamp,Susan A. Wagner,Richard A. Mountford +4 more
TL;DR: The activity of these enzymes in neutrophils could not account for the differences observed but patients with inflammatory bowel disease showed significant increases in acylneuraminate pyruvate-lyase and proteinase activity but sialidase activity did not differ from normal.
Journal ArticleDOI
Exploring the molecular adhesion of ocular mucins.
TL;DR: Short distances of interaction, magnitude of detachment forces, and imaging of mucins on SAM all suggest deformable compact mucin aggregates on the AFM tip, and inter-detachment distances suggest a large degree of interpenetration between neighboring molecules.
Journal ArticleDOI
South Asian and European colitics show characteristic differences in colonic mucus glycoprotein type and turnover.
TL;DR: The appearance of apparently normal mucin in patients with ulcerative colitis may be a useful marker for the identification of a subgroup at low risk of colorectal cancer.