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Antoine Pianos
Researcher at French Institute of Health and Medical Research
Publications - 22
Citations - 1448
Antoine Pianos is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Pregnenolone & Neuroactive steroid. The author has an hindex of 15, co-authored 16 publications receiving 1322 citations. Previous affiliations of Antoine Pianos include University of Paris-Sud & Collège de France.
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Journal ArticleDOI
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Sébastien Weill-Engerer,Jean-Philippe David,Véronique Sazdovitch,Philippe Liere,Bernard Eychenne,Antoine Pianos,Michael Schumacher,André Delacourte,Etienne-Emile Baulieu,Yvette Akwa +9 more
TL;DR: High levels of key proteins implicated in the formation of plaques and neurofibrillary tangles were correlated with decreased brain levels of PREGS and DHEAS, suggesting a possible neuroprotective role of these neurosteroids in AD.
Journal ArticleDOI
Validation of an analytical procedure to measure trace amounts of neurosteroids in brain tissue by gas chromatography-mass spectrometry.
Philippe Liere,Yvette Akwa,Sébastien Weill-Engerer,Bernard Eychenne,Antoine Pianos,P. Robel,Jan Sjövall,Michael Schumacher,Etienne-Emile Baulieu +8 more
TL;DR: The methodology validated here, allows femtomoles of neurosteroids, including the sulfates, found in small brain samples (at least equal to 10 mg) to be quantified simultaneously, and high sensitivity and accuracy were obtained.
Journal ArticleDOI
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain
Marc Verleye,Yvette Akwa,Philippe Liere,Nathalie Ladurelle,Antoine Pianos,Bernard Eychenne,Michael Schumacher,Jean-Marie Gillardin +7 more
TL;DR: Results indicate that following activation of the PBR in the brain, an increased cerebral production of allopregnanolone, a potent positive modulator of the GABA(A) receptor function, may partially contribute to the anxiolytic-like effects of etifoxine.
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Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry.
Delphine Meffre,Antoine Pianos,Philippe Liere,Bernard Eychenne,Annie Cambourg,Michael Schumacher,Donald G. Stein,Rachida Guennoun +7 more
TL;DR: A significant increase in neurosteroid levels in the male brain after TBI is consistent with their role in neuroprotection and in pseudopregnant females, high levels of circulating progestagens may provide protection against TBI.
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Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain
Philippe Liere,Antoine Pianos,Bernard Eychenne,Annie Cambourg,Suya Liu,William J. Griffiths,Michael Schumacher,Jan Sjövall,Etienne-Emile Baulieu +8 more
TL;DR: It is suggested that the discrepancies between analyses with and without deconjugation are caused by internal contamination of brain extract fractions, supposed to contain steroid sulfates, by lipoidal forms of PREG and DHEA (L-PREG and L-DHEA, respectively).