D
Donald G. Stein
Researcher at Emory University
Publications - 280
Citations - 16336
Donald G. Stein is an academic researcher from Emory University. The author has contributed to research in topics: Traumatic brain injury & Neuroprotection. The author has an hindex of 72, co-authored 280 publications receiving 15415 citations. Previous affiliations of Donald G. Stein include Clark University & Rutgers University.
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ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury.
David W. Wright,Arthur L. Kellermann,Vicki S. Hertzberg,Pamela L. Clark,Michael Frankel,Felicia C. Goldstein,Jeffrey P. Salomone,L. Leon Dent,Odette A. Harris,Douglas S. Ander,Douglas W. Lowery,Manish M. Patel,Donald D. Denson,Angelita B. Gordon,Marlena M. Wald,Sanjay Gupta,Stuart W. Hoffman,Donald G. Stein +17 more
TL;DR: Moderate traumatic brain injury survivors who received progesterone were more likely to have a moderate to good outcome than those randomized to placebo and showed possible signs of benefit.
Journal ArticleDOI
The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats
TL;DR: Evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone and allopregnanolone are provided and help to explain why better cognitive performance is observed after injury when animals are given either neurosteroid.
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Brain damage, sex hormones and recovery: a new role for progesterone and estrogen?
TL;DR: A recent clinical trial with estradiol replacement therapy in elderly women that have a history of cerebrovascular disease showed that this hormone was unable to protect against reoccurrence of ischemia or to reduce the incidence of mortality compared to a placebo.
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Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
TL;DR: It is concluded that progesterone and allopregnanolone may attenuate the production of proinflammatory cytokines early after TBI, and this may be one mechanism by which progester one and allanolone reduce cerebral edema and promote functional recovery from TBI.
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Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats.
TL;DR: Progesterone-treated rats were less impaired on a Morris water maze spatial navigation task and showed less neuronal degeneration 21 days after injury in the medial dorsal thalamic nucleus, a structure that has reciprocal connections with the contused area.