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Antonella Casola
Researcher at University of Texas Medical Branch
Publications - 112
Citations - 7187
Antonella Casola is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Chemokine & Human metapneumovirus. The author has an hindex of 50, co-authored 102 publications receiving 6546 citations. Previous affiliations of Antonella Casola include Istituto Superiore di Sanità & University of Naples Federico II.
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Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells
TL;DR: Findings indicate distinct temporal roles of RIG-I and TLR3 in mediating RSV-induced innate immune responses, which are coupled to distinct pathways controlling NF-κB activation.
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Cell-Specific Expression of RANTES, MCP-1, and MIP-1α by Lower Airway Epithelial Cells and Eosinophils Infected with Respiratory Syncytial Virus
Barbara Olszewska-Pazdrak,Antonella Casola,Tadahito Saito,Rafeul Alam,Sheila E. Crowe,Fang C Mei,Pearay L. Ogra,Roberto P. Garofalo +7 more
TL;DR: The inflammatory process in RSV-induced bronchiolitis appears to be triggered by the infection of epithelial cells and further amplified via mechanisms driven by IFN-γ and by the secretion of eosinophil chemokines.
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Respiratory Syncytial Virus–Induced Activation of Nuclear Factor–κB in the Lung Involves Alveolar Macrophages and Toll-Like Receptor 4–Dependent Pathways
Helene A. Haeberle,Ryuta Takizawa,Antonella Casola,Allan R. Brasier,Hans-Juergen Dieterich,Nico van Rooijen,Zoran Gatalica,Roberto P. Garofalo +7 more
TL;DR: RSV potently and specifically activates NF-kappaB in vivo, a process that involves nuclear translocation of the subunits RelA, p50, and c-Rel in the lung, and may be considered a central activator of not only inflammatory but also innate immune responses to RSV.
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Nuclear factor-κB-dependent induction of interleukin-8 gene expression by tumor necrosis factor α : Evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation
TL;DR: Data indicate that TNF induces a delayed ROS-dependent signalling pathway that is required for NF-κB transcriptional activation and is separable from that required for its nuclear translocation.
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Transcriptional Activation of the Interleukin-8 Gene by Respiratory Syncytial Virus Infection in Alveolar Epithelial Cells: Nuclear Translocation of the RelA Transcription Factor as a Mechanism Producing Airway Mucosal Inflammation
Roberto P. Garofalo,Mona Sabry,Mohammad Jamaluddin,Robert K. Yu,Antonella Casola,Pearay L. Ogra,Andallan R. Brasier +6 more
TL;DR: It is concluded that RelA undergoes changes in subcellular distribution in airway epithelial cells upon pRSV infection, and the ability of replicating RSV to activate RelA translocation may play an important role in activating IL-8 and other inflammatory gene products necessary for airway mucosal inflammation seen in RSV disease.