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Antonio Fernández-Ortiz
Researcher at Hospital Clínico San Carlos
Publications - 442
Citations - 16265
Antonio Fernández-Ortiz is an academic researcher from Hospital Clínico San Carlos. The author has contributed to research in topics: Myocardial infarction & Medicine. The author has an hindex of 61, co-authored 399 publications receiving 14356 citations. Previous affiliations of Antonio Fernández-Ortiz include Cardiovascular Institute of the South & Complutense University of Madrid.
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Journal ArticleDOI
Variability in Individual Responsiveness to Clopidogrel: Clinical Implications, Management, and Future Perspectives
Dominick J. Angiolillo,Antonio Fernández-Ortiz,Esther Bernardo,Fernando Alfonso,Carlos Macaya,Theodore A. Bass,Marco A. Costa +6 more
TL;DR: In this article, the impact of individual response variability to clopidogrel on clinical outcomes and current and future directions for its management is reviewed. But, despite the use of clopidine, a considerable number of patients continue to have cardiovascular events.
Journal Article
Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.
Prediman K. Shah,Erling Falk,Juan J. Badimon,Antonio Fernández-Ortiz,Alessandra Mailhac,G Villareal-Levy,John T. Fallon,J Regnstrom,V Fuster +8 more
TL;DR: The hypothesis that increased macrophage density and/or activation in the atherosclerotic plaque may induce collagen breakdown in the fibrous cap by secreting MMPs and possibly other proteases, thus contributing to vulnerability to plaque rupture is supported.
Journal ArticleDOI
Tissue Factor Modulates the Thrombogenicity of Human Atherosclerotic Plaques
Vincenzo Toschi,Richard L. Gallo,M. Lettino,John T. Fallon,S. D. Gertz,Antonio Fernández-Ortiz,James H. Chesebro,Lina Badimon,Yale Nemerson,Valentin Fuster,Juan J. Badimon +10 more
TL;DR: The results show that tissue factor is present in lipid-rich human atherosclerotic plaques and suggest that it is an important determinant of the thrombogenicity of human atheosclerotic lesions after spontaneous or mechanical plaque disruption.
Journal ArticleDOI
Drug-eluting stent thrombosis: results from a pooled analysis including 10 randomized studies.
Raúl Moreno,Cristina Fernández,Rosana Hernández,Fernando Alfonso,Dominick J. Angiolillo,Manel Sabaté,Javier Escaned,Camino Bañuelos,Antonio Fernández-Ortiz,Carlos Macaya +9 more
TL;DR: In this paper, the authors compared the risk of stent thrombosis after drug-eluting stents (DES) versus bare-metal stents and tested the hypothesis that the risk was related to stent length.
Journal ArticleDOI
Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture☆
Antonio Fernández-Ortiz,Juan J. Badimon,Erling Falk,Valentin Fuster,Beat J. Meyer,Alessandra Mailhac,Dan Weng,Prediman Shah,Lina Badimon +8 more
TL;DR: Plaques with a large atheromatous core content are at high risk of leading to acute coronary syndromes after spontaneous or mechanically induced rupture because of the increased thrombogenicity of their content.