A
Anup Kumar Singh
Researcher at Central Drug Research Institute
Publications - 20
Citations - 826
Anup Kumar Singh is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Cancer & Chemokine receptor. The author has an hindex of 11, co-authored 20 publications receiving 623 citations. Previous affiliations of Anup Kumar Singh include Council of Scientific and Industrial Research & City of Hope National Medical Center.
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Journal ArticleDOI
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.
Anup Kumar Singh,Rakesh K. Arya,Arun Kumar Trivedi,Sabyasachi Sanyal,Rathindranath Baral,Olivier Dormond,David M. Briscoe,Dipak Datta +7 more
TL;DR: It is important to consider the interactions and crosstalk between these three chemokine receptors and their ligand mediated signaling cascades for the development of effective anti-cancer therapies.
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The role of poly ADP-ribosylation in the first wave of DNA damage response
TL;DR: This summary of recent findings suggesting that PARylation may be the critical event that mediates the first wave of the DNA damage response discusses the potential for functional crosstalk with other DNA damage-induced post-translational modifications.
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Tumor heterogeneity and cancer stem cell paradigm: updates in concept, controversies and clinical relevance.
Anup Kumar Singh,Rakesh K. Arya,Shrankhla Maheshwari,Shrankhla Maheshwari,Akhilesh Singh,Sanjeev Meena,Priyanka Pandey,Olivier Dormond,Dipak Datta,Dipak Datta +9 more
TL;DR: A path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of cancer stem cells (CSCs) in brain, skin and intestinal tumors using lineage-tracing and thus strengthened the CSC concept.
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EZH2: Not EZHY (Easy) to Deal
TL;DR: A better understanding of the complex epigenetic regulatory network controlling EZH2 expression and target genes facilitates the design of novel therapeutic interventions, and highlights the multifaceted role of EH2, as either a transcriptional activator or repressor depending on the cellular context.
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Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells
Shikha S. Chauhan,Shikha S. Chauhan,Anup Kumar Singh,Sanjeev Meena,Minaxi B. Lohani,Akhilesh Singh,Rakesh K. Arya,Srikanth H. Cheruvu,Jayanta Sarkar,Jiaur R. Gayen,Dipak Datta,Prem M. S. Chauhan +11 more
TL;DR: A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines and found that two of the compounds, 7c and 7d, showed marked anti-proliferative activity in aPanel of solid tumor cell lines with highest effect in breast cancer.