O
Olivier Dormond
Researcher at University of Lausanne
Publications - 77
Citations - 3661
Olivier Dormond is an academic researcher from University of Lausanne. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Angiogenesis. The author has an hindex of 30, co-authored 71 publications receiving 3094 citations. Previous affiliations of Olivier Dormond include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation
Amélie Sabine,Amélie Sabine,Yan Agalarov,Yan Agalarov,Hélène Maby-El Hajjami,Hélène Maby-El Hajjami,Muriel Jaquet,Muriel Jaquet,René Hägerling,Cathrin Pollmann,Damien Bebber,Damien Bebber,Anna Pfenniger,Naoyuki Miura,Olivier Dormond,J. M. Calmes,Ralf H. Adams,Ralf H. Adams,Taija Makinen,Friedemann Kiefer,Brenda R. Kwak,Tatiana V. Petrova,Tatiana V. Petrova +22 more
TL;DR: A model in which regionally increased levels/activation states of transcription factors cooperate with mechanotransduction to induce a discrete cell-signaling pattern and morphogenetic event, such as formation of lymphatic valves is proposed.
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NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.
TL;DR: Results establish a novel functional link between COX-2, integrin αVβ3 and Cdc42-/Rac-dependent endothelial-cell migration and provide a rationale to the understanding of the anti-angiogenic activity of NSAIDs.
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PI3K and AKT: Unfaithful Partners in Cancer
Seraina Faes,Olivier Dormond +1 more
TL;DR: The complex relationship between PI3K and AKT in cancer is highlighted and the consequences for cancer therapy are discussed, revealing another level of complexity in this pathway.
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Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.
Anup Kumar Singh,Rakesh K. Arya,Arun Kumar Trivedi,Sabyasachi Sanyal,Rathindranath Baral,Olivier Dormond,David M. Briscoe,Dipak Datta +7 more
TL;DR: It is important to consider the interactions and crosstalk between these three chemokine receptors and their ligand mediated signaling cascades for the development of effective anti-cancer therapies.
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Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling
TL;DR: It is demonstrated that PGE2 accelerates αVβ3-mediated endothelial cell adhesion through cAMP-dependent PKA activation and induces αV β3-dependent spreading via camp- and PKA-dependent Rac activation and may contribute to the further understanding of the regulation of vascular integrins αvβ3 by COX-2/PGE2 during tumor angiogenesis and inflammation.