A
Anupama Ganesh
Researcher at University of California, Davis
Publications - 5
Citations - 401
Anupama Ganesh is an academic researcher from University of California, Davis. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 4, co-authored 5 publications receiving 342 citations.
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Journal ArticleDOI
Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection
Edwin Leeansyah,Anupama Ganesh,Máire F. Quigley,Anders Sönnerborg,Jan Andersson,Peter W. Hunt,Ma Somsouk,Steven G. Deeks,Jeffrey N. Martin,Markus Moll,Barbara L. Shacklett,Johan K. Sandberg +11 more
TL;DR: Interestingly, MAIT cells in rectal mucosa were relatively preserved, although some of the changes seen in blood were recapitulated in the mucosa, consistent with a model in which the MAIT-cell compartment is engaged, activated, exhausted, and progressively and persistently depleted during chronic HIV-1 infection.
Journal ArticleDOI
Detection of HIV-1-specific gastrointestinal tissue resident CD8 + T-cells in chronic infection
Brenna E. Kiniry,Shengbin Li,Anupama Ganesh,Peter W. Hunt,Ma Somsouk,Pamela J. Skinner,Steven G. Deeks,Barbara L. Shacklett +7 more
TL;DR: Findings suggest a large fraction of CD8+ T-cells housed in the human rectosigmoid mucosa are tissue-resident and that TRM contribute to the anti-HIV-1 immune response.
Journal ArticleDOI
Predominance of weakly cytotoxic, T-bet Low Eomes Neg CD8 + T-cells in human gastrointestinal mucosa: implications for HIV infection
Brenna E. Kiniry,Anupama Ganesh,J. W. Critchfield,Peter W. Hunt,Frederick Hecht,Ma Somsouk,Steven G. Deeks,Barbara L. Shacklett +7 more
TL;DR: It is suggested that rectal CD8+ T-cells are primarily non-cytotoxic, and phenotypically shaped by the tissue microenvironment, and further elucidation of rectal immune responses to HIV will inform the development of vaccines and immunotherapies targeted to mucosal tissues.
Journal ArticleDOI
Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers.
Anupama Ganesh,Donna Lemongello,Evelyn Lee,Julia Peterson,Bridget McLaughlin,April L. Ferre,Geraldine M. Gillespie,Dietmar Fuchs,Steven G. Deeks,Peter W. Hunt,Richard W. Price,Serena Spudich,Barbara L. Shacklett +12 more
TL;DR: In this article, a study was conducted to determine whether HIV-specific CD8+ T cells are present in CSF of HIV controllers, who maintain low to undetectable plasma viremia without antiretroviral therapy (ART).
MR1-restricted MAIT-cell population in chronic HIV-1 infection Activation, exhaustion, and persistent decline of the antimicrobial
Johan K. Sandberg,William F. Hunt,Steven Deeks,Jeffrey N. Martin,Barbara L. Shacklett,Edwin Leeansyah,Anupama Ganesh,Máire F. Quigley,Anders Sönnerborg,Jan Andersson +9 more