Máire F. Quigley

TL;DR: A long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells is described.

TL;DR: Interestingly, MAIT cells in rectal mucosa were relatively preserved, although some of the changes seen in blood were recapitulated in the mucosa, consistent with a model in which the MAIT-cell compartment is engaged, activated, exhausted, and progressively and persistently depleted during chronic HIV-1 infection.

TL;DR: Convergent recombination shapes the TCR repertoire of the memory and naive T cell pools, as well as their interrelationship within and between individuals.

TL;DR: The results indicate that the cytolytic capacity in MAIT cells is severely defective in HIV-1 infected patients, and that the broad-based functional defect in these cells is associated with deficiency in critical transcription factors.

TL;DR: The clinical experience with adoptive transfer of allogeneic hematopoietic stem cell transplantation donor-derived virus-specific CTLs is reviewed, and it is found that virus- specific T cell lines recognized up to 10% of a panel of 44 HLA disparate targets, indicating that virus -specific T cells can have cross-reactivity with HLA-mismatched targets in vitro.