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Ariel R. Ase
Researcher at Montreal Neurological Institute and Hospital
Publications - 53
Citations - 2382
Ariel R. Ase is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Receptor & Dopamine. The author has an hindex of 28, co-authored 53 publications receiving 2106 citations. Previous affiliations of Ariel R. Ase include McGill University & Université de Montréal.
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Journal ArticleDOI
Functional Evidence that BDNF Is an Anterograde Neuronal Trophic Factor in the CNS
James P. Fawcett,Shernaz X. Bamji,Carrie G. Causing,Raquel Aloyz,Ariel R. Ase,Tomás A. Reader,John H. McLean,Freda D. Miller +7 more
TL;DR: Results indicate that BDNF is anterogradely transported to fibers and terminals of noradrenergic neurons, that anterogsradely secreted BDNF causes activation of TrkB in target regions, and that this secretion has functional consequences for target neuron survival and differentiation.
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Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice
Ihab Daou,Alexander H. Tuttle,Geraldine Longo,Jeffrey S. Wieskopf,Robert P. Bonin,Ariel R. Ase,John N. Wood,Y. De Koninck,A. Ribeiro-da-Silva,Jeffrey S. Mogil,Philippe Séguéla +10 more
TL;DR: These findings demonstrate, for the first time, the optical control of nociception and central sensitization in behaving mammals and enables selective activation of the same class of afferents in both in vivo and ex vivo preparations.
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P2Y12 expression and function in alternatively activated human microglia
Craig S. Moore,Ariel R. Ase,Angham Kinsara,Vijayaraghava T.S. Rao,Mackenzie A. Michell-Robinson,Soo Yuen Leong,Oleg Butovsky,Samuel K. Ludwin,Philippe Séguéla,Amit Bar-Or,Jack P. Antel +10 more
TL;DR: In vitro and in situ experiments confirm that P2Y12 is selectively expressed on human microglia and elevated under neuropathologic conditions that promote Th2 responses, such as parasitic CNS infection and suggest a mechanism to selectively target a functionally unique population of myeloid cells in the CNS.
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Parkin-mediated Monoubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels
Monica Joch,Ariel R. Ase,Carol X.-Q. Chen,Penny A. MacDonald,Maria Kontogiannea,Amadou T. Corera,Alexis Brice,Philippe Séguéla,Edward A. Fon +8 more
TL;DR: This work provides a mechanism explaining how defects in parkin-mediated PICK1 monoubiquitination could enhance ASIC activity and thereby promote neurodegeneration in Parkinson's disease.
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P2X receptor channels in chronic pain pathways.
TL;DR: The contribution of P 2X3, P2X4 and P2x7 receptors to chronic pain is reviewed and the opportunities and challenges associated with the pharmacological manipulation of their function are discussed.