O
Oleg Butovsky
Researcher at Brigham and Women's Hospital
Publications - 112
Citations - 18157
Oleg Butovsky is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Microglia & Neurodegeneration. The author has an hindex of 44, co-authored 95 publications receiving 13270 citations. Previous affiliations of Oleg Butovsky include Boston University & Weizmann Institute of Science.
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Journal ArticleDOI
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: It is found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adultmicroglia and that microglian were absent in the CNS of TGF -β1–deficient mice.
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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
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Microglia Function in the Central Nervous System During Health and Neurodegeneration.
Marco Colonna,Oleg Butovsky +1 more
TL;DR: The complexity of targeting microglia for therapeutic intervention in neurodegenerative diseases is highlighted and the spectrum of microglial phenotypes during development, homeostasis, and disease is characterized.
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Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
Yaniv Ziv,Noga Ron,Oleg Butovsky,Gennady Landa,Einav Sudai,Nadav Greenberg,Hagit Cohen,Jonathan Kipnis,Jonathan Kipnis,Michal Schwartz +9 more
TL;DR: This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood and suggests that a common immune-associated mechanism underlies different aspects of hippocampusal plasticity and cell renewal in the adult brain.
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Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Hirohide Asai,Seiko Ikezu,Satoshi Tsunoda,Maria Medalla,Jennifer I. Luebke,Tarik F. Haydar,Benjamin Wolozin,Oleg Butovsky,Sebastian Kügler,Tsuneya Ikezu +9 more
TL;DR: It is found that depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model, and this data suggest that microglian involvement in tau propagation and the exosome secretion pathway may be a therapeutic target.