A
Arjun Raj
Researcher at University of Pennsylvania
Publications - 142
Citations - 21547
Arjun Raj is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 50, co-authored 131 publications receiving 18166 citations. Previous affiliations of Arjun Raj include Rutgers University & University of California, San Diego.
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Journal ArticleDOI
Systems biology: Molecular memoirs of a cellular family
Lauren E. Beck,Arjun Raj +1 more
TL;DR: A system that introduces random modifications to barcode sequences embedded in cells' DNA allows lineage relationships between cells to be discerned, while preserving the cells' spatial relationships.
Posted ContentDOI
Systematically quantifying morphological features reveals constraints on organoid phenotypes
Lauren E. Beck,Jasmine Lee,Christopher Coté,Margaret C. Dunagin,Nikkita Salla,Marcello Chang,Alex J. Hughes,Joseph D Mornin,Zev J. Gartner,Arjun Raj +9 more
TL;DR: In this article, the authors establish a framework to identify constraints on an organoid's morphological features by quantifying them from microscopy images of organoids exposed to a range of perturbations.
Posted ContentDOI
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence
Jie Xu,Yan Sun,Yize Li,Gordon Ruthel,Susan R. Weiss,Arjun Raj,Daniel P. Beiting,Carolina B. López +7 more
TL;DR: TNF is identified as a pivotal factor in determining cell fate during a viral infection and a MAVS/TNFR2-mediated mechanism that drives the persistence of otherwise acute viruses is delineated.
Posted ContentDOI
Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity
Ian A. Mellis,Hailey I. Edelstein,Rachel Truitt,Lauren E. Beck,Orsolya Symmons,Yogesh Goyal,Margaret C. Dunagin,Ricardo A. Linares Saldana,Parisha P. Shah,Wenli Yang,Rajan Jain,Arjun Raj +11 more
TL;DR: Perturbation Panel Profiling (P3) was developed as a framework for perturbing cells in dozens of conditions and measuring gene expression responsiveness transcriptome-wide and it was proposed that responsiveness to perturbations is a property of factors that help maintain cellular identity.
Posted ContentDOI
Metastatic potential in clonal melanoma cells is driven by a rare, early-invading subpopulation
Amanpreet Kaur,Luciann Cuenca,Karun Kiani,Gianna T. Busch,Dylan Fingerman,Margaret C. Dunagin,Jingxin Li,Ian Dardani,Eric M. Sanford,Jordan Pemberton,Yogesh Goyal,Ashani T. Weeraratna,Meenhard Herlyn,Arjun Raj +13 more
TL;DR: It is shown that rare, highly invasive melanoma cells can appear even within clonal cell lines due to non-genetic fluctuations, and these differences were intrinsic to the cells independent of their external context, and were marked by transiently high levels of SEMA3C expression.