O
Orsolya Symmons
Researcher at University of Pennsylvania
Publications - 31
Citations - 1854
Orsolya Symmons is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 14, co-authored 28 publications receiving 1497 citations. Previous affiliations of Orsolya Symmons include École normale supérieure de Lyon & Max Planck Society.
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Phenotypic impact of genomic structural variation: insights from and for human disease
TL;DR: This Review describes how structural variants can affect molecular and cellular processes, leading to complex organismal phenotypes, including human disease, and presents advances in delineating disease-causing elements that are affected by structural variants.
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Functional and topological characteristics of mammalian regulatory domains
Orsolya Symmons,Veli Vural Uslu,Taro Tsujimura,Sandra Ruf,Sonya Nassari,Wibke Schwarzer,Laurence Ettwiller,François Spitz +7 more
TL;DR: A large operational analysis to chart the distribution of gene regulatory activities along the mouse genome, using hundreds of insertions of a regulatory sensor finds that enhancers distribute their activities along broad regions and not in a gene-centric manner, defining large regulatory domains.
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What's Luck Got to Do with It: Single Cells, Multiple Fates, and Biological Nondeterminism.
Orsolya Symmons,Arjun Raj +1 more
TL;DR: A framework for classifying both the origins of the differences between individual cells and the consequences of those differences is provided, and it is proposed that rigorous definitions of inputs and outputs may bring clarity to the discussion.
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The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances
Orsolya Symmons,Leslie Pan,Silvia Remeseiro,Tugce Aktas,Felix A. Klein,Wolfgang Huber,François Spitz +6 more
TL;DR: It is indicated that the Shh TAD promotes distance-independent contacts between distant regions that would otherwise interact only sporadically, enabling functional communication between them, and could be as essential for gene expression as the formation of insulated neighborhoods.
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Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
Sandra Ruf,Orsolya Symmons,Veli Vural Uslu,Dirk Dolle,Chloé Hot,Laurence Ettwiller,François Spitz +6 more
TL;DR: The local hopping property of Sleeping Beauty provides a dynamic approach to map these regulatory domains at high resolution and, combined with Cre-mediated recombination, allows for the determination of their functions by engineering mice with specific chromosomal rearrangements.