Margaret C. Dunagin

TL;DR: It is shown that human melanoma cells can display profound transcriptional variability at the single-cell level that predicts which cells will ultimately resist drug treatment, and this work reveals the multistage nature of the acquisition of drug resistance and provides a framework for understanding resistance dynamics in single cells.

TL;DR: A systematic, high-resolution survey of lncRNA localization reveals aspects of lNCRNAs that are similar to mRNAs, such as cell-to-cell variability, but also several distinct properties that may correspond to particular functional roles.

TL;DR: In these highly inflammatory cells, changes in Morrbid levels provide a locus-specific regulatory mechanism that allows rapid control of apoptosis in response to extracellular pro-survival signals.

TL;DR: These findings demonstrate the interaction of esophageal cancer and cancer-associated fibroblasts through IL-6 signaling, providing rationale for a novel therapeutic approach to target these cancers.

TL;DR: RNA interference assays of 21 abundant erythroid-specific murine lncRNAs in primary mouse erystroid precursors identified 7 whose knockdown inhibited terminal erythyroid maturation, suggesting that lack of conservation between mammalian species does not predict lack of function.