Arjun Raj

TL;DR: This paper describes and characterizes a tool that allows researchers to crowdsource image-annotation tasks and shows equivalent deep learning performance for Quanti.us-derived and expert-derived annotations, which should allow scalable integration with tailored machine learning algorithms.

TL;DR: For certain classes of fractal differential equations on the Sierpinski gasket, built using the Kigami Laplacian, it is described how to approximate solutions using the finite element method based on piecewise harmonic or piecewise biharmonic splines.

TL;DR: One lncRNA, Firre, is described that interacts with the nuclear matrix factor hnRNPU through a 156 bp repeating sequence and Firre localizes across a ~5 Mb domain on the X-chromosome, suggesting a model in which lncRNAs such as Firre can interface with and modulate nuclear architecture across chromosomes.

TL;DR: This work performs extensive single cell analysis to identify differences in gene expression and MAP-kinase signaling that mark a rare population of drug-naive cells that ultimately gives rise to drug resistant clones, and demonstrates that this rare subpopulation has rich substructure and is composed of several distinct subpopulations.

TL;DR: The results establish that imprinting disorders can display striking single-cell heterogeneity in their molecular phenotypes and suggest that such heterogeneity may underlie epigenetic mosaicism in human imprinting Disorders.