Ian A. Mellis

TL;DR: It is suggested that although age-related physical changes in the ECM can promote tumor cell motility, they may adversely affect the motility of some immune cells, resulting in an overall change in the immune microenvironment.

TL;DR: ClampFISH as discussed by the authors is a click-amplifying FISH that achieves high specificity and high-gain (>400-fold) signal amplification by ligating the ends of the probes together using bio-orthogonal click chemistry, effectively locking the probes around the target.

TL;DR: A new design for conditional alleles that uses an optimized conditional gene trap module inserted into the target gene in an orientation opposite to the gene’s direction of transcription, greatly simplifying allele design and increasing flexibility over previous conditional KO approaches is described.

TL;DR: Evaluated relationships among 17 biomarkers previously reported to associate with cognition in Parkinson’s disease or AD to test performance of a five-biomarker classifier trained to recognize AD in identifying PD with dementia (PDD), suggesting mechanisms shared with AD in some PDD patients.

TL;DR: InoFISH is developed to directly visualize and quantify adenosine-to-inosine-edited transcripts in situ and finds that editing of the GRIA2, EIF2AK2, and NUP43 transcripts is uncorrelated with nuclear localization and paraspeckle association.