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Arlene K. Ngor
Researcher at University of California, Irvine
Publications - 4
Citations - 100
Arlene K. Ngor is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Chemistry & Nucleic acid. The author has an hindex of 2, co-authored 3 publications receiving 56 citations.
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Evolution of a General RNA-Cleaving FANA Enzyme
TL;DR: An efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) that functions with a rate enhancement of >106-fold over the uncatalyzed reaction and exhibits substrate saturation kinetics typical of most natural enzymes is described.
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P(V) Reagents for the Scalable Synthesis of Natural and Modified Nucleoside Triphosphates
TL;DR: A fundamental-ly different approach is described that uses a novel P(V) pyrene pyro-phosphate reagent to generate derivatives that are purified by silica gel chromatography and converted to the desired compounds on scales vastly exceeding those achievable by HPLC.
Journal ArticleDOI
Evolution of Functionally Enhanced α-l-Threofuranosyl Nucleic Acid Aptamers.
Cailen M McCloskey,Qingfeng Li,Eric J. Yik,Nicholas Chim,Arlene K. Ngor,Esau Medina,Ivan Grubisic,Lance Co Ting Keh,Ryan Poplin,John C. Chaput +9 more
TL;DR: In this article, the authors describe the evolution of a biologically stable artificial genetic system composed of α-l-threofuranosyl nucleic acid (TNA) that facilitates the production of backbone and base-modified aptamers termed "threomers" that function as high quality protein capture reagents.
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REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples
TL;DR: REVEALR is designed into a novel genotyping assay that detects single-base mismatches corresponding to each of the major SARS-CoV-2 strains found in the United States, and offers an important new approach to personalized diagnostics.