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Arlene M. Manelli
Researcher at NorthShore University HealthSystem
Publications - 21
Citations - 3330
Arlene M. Manelli is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Apolipoprotein E & Amyloid precursor protein. The author has an hindex of 18, co-authored 20 publications receiving 3172 citations. Previous affiliations of Arlene M. Manelli include University of Illinois at Chicago.
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Journal ArticleDOI
Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability
Karie N. Dahlgren,Arlene M. Manelli,W. Blaine Stine,Lorinda K. Baker,Grant A. Krafft,Grant A. Krafft,Mary Jo LaDu +6 more
TL;DR: Data demonstrate that protocols developed to produce oligomeric and fibrillar Aβ-(1–42) are useful in distinguishing the structural and functional differences between A β-(1-42) and Aβ-1–40 and genetic mutations of Aβ.
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Isoform-specific binding of apolipoprotein E to beta-amyloid.
Mary Jo LaDu,Michael T. Falduto,Arlene M. Manelli,Catherine A. Reardon,Godfrey S. Getz,Donald E. Frail +5 more
TL;DR: Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of Alzheimer's disease, and the presence of an approximately 45-kDa complex with both A beta and apoE immunoreactivity is revealed.
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Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation
Jill A. White,Arlene M. Manelli,Kristina H. Holmberg,Kristina H. Holmberg,Linda J. Van Eldik,Mary Jo LaDu,Mary Jo LaDu +6 more
TL;DR: The results suggest that oligomers induced a profound, early inflammatory response, whereas fibrillar Abeta showed less increase of pro-inflammatory molecules, consistent with a more chronic form of inflammation.
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Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Katherine L. Youmans,Leon M. Tai,Takahisa Kanekiyo,W. Blaine Stine,Sara Claude Michon,Evelyn Nwabuisi-Heath,Arlene M. Manelli,Yifan Fu,Sean M. Riordan,William A. Eimer,Lester I. Binder,Guojun Bu,Chunjiang Yu,Dean M. Hartley,Mary Jo LaDu +14 more
TL;DR: Both intraneuronal Aβ accumulation and extracellular A β deposition was demonstrated in 5xFAD mice and 3xTg mice with MOAB-2, an antibody that will help differentiate intracellular Aβ from APP, however, further investigation is required to determine whether a molecular mechanism links the presence of intraneuonal A β with neurotoxicity.
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Serine mutations in transmembrane V of the dopamine D1 receptor affect ligand interactions and receptor activation
TL;DR: The results suggest that serines present in transmembrane V of the D1 receptor affect ligand interactions and receptor signal transduction, but not entirely in the manner that would be predicted from the model proposed for the beta-adrenergic receptor.