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Arooma Maryam
Researcher at COMSATS Institute of Information Technology
Publications - 18
Citations - 259
Arooma Maryam is an academic researcher from COMSATS Institute of Information Technology. The author has contributed to research in topics: Chemistry & Cyclase. The author has an hindex of 7, co-authored 16 publications receiving 177 citations. Previous affiliations of Arooma Maryam include Istanbul University & Government College University, Faisalabad.
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Computational screening of medicinal plant phytochemicals to discover potent pan-serotype inhibitors against dengue virus.
Muhammad Tahir ul Qamar,Arooma Maryam,Iqra Muneer,Feng Xing,Usman Ali Ashfaq,Faheem Ahmed Khan,Farooq Anwar,Mohammed H. Geesi,Rana Rehan Khalid,Sadaf Abdul Rauf,Abdul Rauf Siddiqi +10 more
TL;DR: Novel scaffolds against DV serotypes are brought forth to serve as lead molecules for further optimization and drug development against all DV serotype heterotypic re-infection with equal effect against multiple disease causing DV proteins.
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Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach
Muhammad Tahir ul Qamar,Amna Bari,Muhammad Adeel,Arooma Maryam,Usman Ali Ashfaq,Xiaoyong Du,Iqra Muneer,Hafiz Ishfaq Ahmad,Jia Wang +8 more
TL;DR: The study led to the discovery of various epitopes, conserved among various strains belonging to different countries, which can be successfully utilized in designing novel vaccines for combating and eradication of CHIKV disease.
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Comparative Studies of the Dynamics Effects of BAY60-2770 and BAY58-2667 Binding with Human and Bacterial H-NOX Domains
Rana Rehan Khalid,Muhammad Tahir ul Qamar,Arooma Maryam,Ayesha Ashique,Farooq Anwar,Mohammed H. Geesi,Abdul Rauf Siddiqi +6 more
TL;DR: Comparative molecular dynamics studies revealed that BAY bound bHNOX dynamics varied from that of hH-NOX, plausibly due to some key residues such as R40, F74 and Y112 which are not conserved in bacteria.
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The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa
Arooma Maryam,Arooma Maryam,Sundeep Chaitanya Vedithi,Rana Rehan Khalid,Ali F. Alsulami,Pedro Henrique Monteiro Torres,Abdul Rauf Siddiqi,Tom L. Blundell +7 more
TL;DR: A possible link of change in PDE6αβ structural stability to the experimentally observed disease phenotypes is established and an integrated knowledge-driven in silico mutation analysis approach is applied.
Journal Article
Anticancer screening of medicinal plant phytochemicals against Cyclin-Dependent Kinase-2 (CDK2): An in-silico approach
Wajahat Khan,Usman Ali Ashfaq,Sadia Aslam,Sidra Saif,Tehzeeb Aslam,Kishver Tusleem,Arooma Maryam,Muhammad Tahir ul Qamar +7 more
TL;DR: These phytochemicals can be considered as potential anticancer agents and used in drug development against CDK2 and pave way for phytochemical based novel small molecules as more efficacious and selective anti-cancer therapeutic compounds.