Arshad H. Khan

TL;DR: The mouse brain peptide/protein database generated from this study represents the most comprehensive proteome coverage for the mammalian brain to date, and the basis for future quantitative brain proteomic studies using mouse models.

TL;DR: The combined protein and gene list provides a clearer picture of the potential mechanisms underlying neurodegeneration observed in PD, including mitochondrial dysfunction, oxidative stress response, and apoptosis.

TL;DR: The architecture of brain transcript regulation is surveyed and preservation of gene co-expression modules in hippocampus and striatum is demonstrated, while also highlighting important differences.

TL;DR: Using microarrays, voxel images of coronal hemisections at the level of the hippocampus of both the normal human brain and Alzheimer's disease brain were acquired and revealed a common network of coregulated genes, and allowed identification of putative control regions.

TL;DR: The investigation revealed a common network of coregulated genes shared between the normal and PD brain, and allowed identification of putative control regions responsible for these networks, and genes involved in cell/cell interactions were found to be prominently regulated in the PD brains.