R
Ronald J. Moore
Researcher at Pacific Northwest National Laboratory
Publications - 185
Citations - 16228
Ronald J. Moore is an academic researcher from Pacific Northwest National Laboratory. The author has contributed to research in topics: Proteome & Proteomics. The author has an hindex of 57, co-authored 171 publications receiving 13299 citations. Previous affiliations of Ronald J. Moore include G. D. Searle & Company & University of California, Los Angeles.
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Journal Article
Antiangiogenic and Antitumor Activities of Cyclooxygenase-2 Inhibitors
Jaime L. Masferrer,Kathleen M. Leahy,Alane T. Koki,Ben S. Zweifel,Steven L. Settle,B M Woerner,D A Edwards,A G Flickinger,Ronald J. Moore,Karen Seibert +9 more
TL;DR: Evidence that cyclooxygenase (COX)-2-derived prostaglandins contribute to tumor growth by inducing newly formed blood vessels (neoangiogenesis) that sustain tumor cell viability and growth and a novel application of this anti-inflammatory drug in the treatment of human cancer is provided.
Journal ArticleDOI
Toward a Human Blood Serum Proteome Analysis By Multidimensional Separation Coupled With Mass Spectrometry
Joshua N. Adkins,Susan M. Varnum,Kenneth J. Auberry,Ronald J. Moore,Nicolas H. Angell,Richard D. Smith,David L. Springer,Joel G. Pounds +7 more
TL;DR: This study has performed the most extensive analysis of serum proteins to date and laid the foundation for future refinements in the identification of novel protein biomarkers of disease.
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Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer
Hui Zhang,Tao Liu,Zhen Zhang,Samuel H. Payne,Bai Zhang,Jason E. McDermott,Jian-Ying Zhou,Vladislav A. Petyuk,Li Chen,Debjit Ray,Shisheng Sun,Feng Yang,Lijun Chen,Jing Wang,Punit Shah,Seong Won Cha,Paul Aiyetan,Sunghee Woo,Yuan Tian,Marina A. Gritsenko,Therese R. W. Clauss,Caitlin H. Choi,Matthew E. Monroe,Stefani N. Thomas,Song Nie,Chaochao Wu,Ronald J. Moore,Kun-Hsing Yu,David L. Tabb,David Fenyö,Vineet Bafna,Yue Wang,Henry Rodriguez,Emily S. Boja,Tara Hiltke,Robert Rivers,Lori J. Sokoll,Heng Zhu,Ie Ming Shih,Leslie Cope,Akhilesh Pandey,Bing Zhang,Michael Snyder,Douglas A. Levine,Richard D. Smith,Daniel W. Chan,Karin D. Rodland,Steven A. Carr,Michael A. Gillette,Karl R. Klauser,Eric Kuhn,D. R. Mani,Philipp Mertins,Karen A. Ketchum,Ratna R. Thangudu,Shuang Cai,Mauricio Oberti,Amanda G. Paulovich,Jeffrey R. Whiteaker,Nathan Edwards,Peter B. McGarvey,Subha Madhavan,Pei Wang,Gordon Whiteley,Steven J. Skates,Forest M. White,Christopher R. Kinsinger,Mehdi Mesri,Kenna M. Shaw,Stephen E. Stein,Paul A. Rudnick,Michael Snyder,Yingming Zhao,Xian Chen,David F. Ransohoff,Andrew N. Hoofnagle,Daniel C. Liebler,Melinda E. Sanders,Zhiao Shi,Robbert J.C. Slebos,Lisa J. Zimmerman,Sherri R. Davies,Li Ding,Matthew J. Ellis,R. Reid Townsend +84 more
TL;DR: A view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC is provided.
Journal ArticleDOI
Reversed‐phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells
Yuexi Wang,Feng Yang,Marina A. Gritsenko,Yingchun Wang,Therese R. W. Clauss,Tao Liu,Yufeng Shen,Matthew E. Monroe,Daniel Lopez-Ferrer,Theresa A. Reno,Ronald J. Moore,Richard L. Klemke,David G. Camp,Richard D. Smith +13 more
TL;DR: The results demonstrate that the concatenated high pH reversed‐phased strategy is an attractive alternative to strong cation exchange for two‐dimensional shotgun proteomic analysis of trypsin‐digested human MCF10A cell sample.
Journal ArticleDOI
Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.
Suhas Vasaikar,Chen Huang,Xiaojing Wang,Vladislav A. Petyuk,Sara R. Savage,Bo Wen,Yongchao Dou,Yun Zhang,Zhiao Shi,Osama A. Arshad,Marina A. Gritsenko,Lisa J. Zimmerman,Jason E. McDermott,Therese R. W. Clauss,Ronald J. Moore,Rui Zhao,Matthew E. Monroe,Yi-Ting Wang,Matthew C. Chambers,Robbert J.C. Slebos,Ken S. Lau,Qianxing Mo,Li Ding,Matthew J. Ellis,Mathangi Thiagarajan,Christopher R. Kinsinger,Henry Rodriguez,Richard D. Smith,Karin D. Rodland,Karin D. Rodland,Daniel C. Liebler,Tao Liu,Bing Zhang,Akhilesh Pandey,Amanda G. Paulovich,Andrew N. Hoofnagle,D. R. Mani,Daniel W. Chan,David F. Ransohoff,David Fenyö,David L. Tabb,Douglas A. Levine,Emily S. Boja,Eric Kuhn,Forest M. White,Gordon Whiteley,Heng Zhu,Hui Zhang,Ie Ming Shih,Jasmin H. Bavarva,Jeffrey R. Whiteaker,Karen A. Ketchum,Karl R. Clauser,Kelly V. Ruggles,Kimberly Elburn,Linda Hannick,Mark A. Watson,Mauricio Oberti,Mehdi Mesri,Melinda E. Sanders,Melissa Borucki,Michael A. Gillette,Michael Snyder,Nathan Edwards,Negin Vatanian,Paul A. Rudnick,Peter B. McGarvey,Philip Mertins,R. Reid Townsend,Ratna R. Thangudu,Robert Rivers,Samuel H. Payne,Sherri R. Davies,Shuang Cai,Stephen E. Stein,Steven A. Carr,Steven J. Skates,Subha Madhavan,Tara Hiltke,Xian Chen,Yingming Zhao,Yue Wang,Zhen Zhang +82 more
TL;DR: Comparative proteomic and phosphoproteomic analysis of paired tumor and normal adjacent tissues produced a catalog of colon cancer-associated proteins and phosphosites, including known and putative new biomarkers, drug targets, and cancer/testis antigens, which suggested glycolysis as a potential target to overcome the resistance of MSI-H tumors to immune checkpoint blockade.