A
Arthur Brown
Researcher at United States Department of the Army
Publications - 81
Citations - 2233
Arthur Brown is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Virus & Plasmodium falciparum. The author has an hindex of 26, co-authored 81 publications receiving 2195 citations. Previous affiliations of Arthur Brown include University of Illinois at Chicago.
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Journal ArticleDOI
Safety and immunogenicity of an HIV subtype B and E prime-boost vaccine combination in HIV-negative Thai adults
Sorachai Nitayaphan,Punnee Pitisuttithum,Chitraporn Karnasuta,Chirapa Eamsila,Mark de Souza,Patricia Morgan,Victoria R. Polonis,Michael Benenson,Tom VanCott,Silvia Ratto-Kim,Jerome H. Kim,Darawan Thapinta,Robin P. Garner,Valai Bussaratid,Pricha Singharaj,Raphaelle El Habib,Sanjay Gurunathan,William L. Heyward,Deborah L. Birx,John J McNeil,Arthur Brown +20 more
TL;DR: The ALVAC-HIV and AIDSVAX B/E vaccine combination was well tolerated and was immunogenic, meeting milestones for advancement to phase 3 evaluation.
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Demonstration by the polymerase chain reaction of mixed Plasmodium falciparum and P. vivax infections undetected by conventional microscopy.
TL;DR: A prospective 'blinded' comparison of diagnosis by conventional light microscopy and enzymatic amplification of the circumsporozoite gene extracted from dried spotted blood samples found P. falciparum and P. vivax infections to be mixed by the PCR/DNA probe systems.
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Detection of plasmodium falciparum by polymerase chain reaction in a field study
TL;DR: The ease of collection and transport of filter-paper specimens combined with the sensitive and specific detection of allelic genes of P. vivax by PCR suggests that this method may prove to be a valuable tool for epidemiologic and heterogeneity studies of the parasite.
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A new circulating recombinant form, CRF15_01B, reinforces the linkage between IDU and heterosexual epidemics in Thailand.
Sodsai Tovanabutra,Veerachai Watanaveeradej,Kwanjai Viputtikul,Mark de Souza,Myat Htoo Razak,Vinai Suriyanon,Jaroon Jittiwutikarn,Somchai Sriplienchan,Sorachai Nitayaphan,Michael Benenson,Narongrid Sirisopana,Philip O. Renzullo,Arthur Brown,Merlin L. Robb,Chris Beyrer,David D. Celentano,John G. McNeil,Deborah L. Birx,Jean K. Carr,Francine E. McCutchan +19 more
TL;DR: It is established that one particular CRF_01B recombinant, with the external envelope of subtype B and the rest of the genome from CRF01_AE, is circulating widely in Thailand, and the previously separate heterosexual and IDU epidemics have apparently been bridged by a new CRF.
Journal ArticleDOI
Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX® B/E prime-boost HIV-1 vaccine trial in Thailand
Chitraporn Karnasuta,Robert Paris,Josephine H. Cox,Sorachai Nitayaphan,Punnee Pitisuttithum,Prasert Thongcharoen,Arthur Brown,Sanjay Gurunathan,James Tartaglia,William L. Heyward,John G. McNeil,Deborah L. Birx,Mark de Souza +12 more
TL;DR: The results demonstrate that this HIV vaccine is a potent inducer of ADCC activity and may be an additional protection of this prime-boost vaccine in preventing HIV disease.