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Arthur D. Lander
Researcher at University of California, Irvine
Publications - 164
Citations - 13790
Arthur D. Lander is an academic researcher from University of California, Irvine. The author has contributed to research in topics: NIPBL & Neurite. The author has an hindex of 65, co-authored 154 publications receiving 13064 citations. Previous affiliations of Arthur D. Lander include University of California, Berkeley & California Institute of Technology.
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Journal ArticleDOI
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons
TL;DR: Current ideas concerning the roles of cell adhesion molecules and cell interactions are discussed, both in development and in several physiological and pathological processes, attempting to highlight the general features and commonalities and presenting working hypotheses.
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Cornelia de Lange syndrome is caused by mutations in NIPBL , the human homolog of Drosophila melanogaster Nipped-B
Ian D. Krantz,Jennifer McCallum,Cheryl DeScipio,Maninder Kaur,Lynette A. Gillis,Dinah Yaeger,Lori Jukofsky,Nora Wasserman,Armand Bottani,Colleen A. Morris,Małgorzata J.M. Nowaczyk,Helga V. Toriello,Michael J. Bamshad,John C. Carey,Eric F. Rappaport,Shimako Kawauchi,Arthur D. Lander,Anne L. Calof,Hui Hua Li,Marcella Devoto,Laird G. Jackson +20 more
TL;DR: The genomic structure of NIPBL is characterized and it is found that it is widely expressed in fetal and adult tissues and facilitates enhancer-promoter communication and regulates Notch signaling and other developmental pathways in Drosophila melanogaster.
Journal ArticleDOI
Do Morphogen Gradients Arise by Diffusion
TL;DR: It is found that diffusive mechanisms of morphogen transport are much more plausible-and nondiffusive mechanisms much less plausible-than has generally been argued.
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Differential binding of chemokines to glycosaminoglycan subpopulations
Daniel P. Witt,Arthur D. Lander +1 more
TL;DR: Chemokines can bind selectively to subsets of heparin/heparan sulfate glycosaminoglycans, raising the possibility that glycosamines participate in determining the specificity of leukocyte recruitment in vivo.
Journal ArticleDOI
The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer.
Jörg Kleeff,Toshiyuki Ishiwata,Asli Kumbasar,Asli Kumbasar,Helmut Friess,Markus W. Büchler,Arthur D. Lander,Murray Korc +7 more
TL;DR: It is proposed that glypican-1 plays an essential role in the responses of pancreatic cancer cells to certain mitogenic stimuli, that it is relatively unique in relation to other HSPGs, and that its expression by pancreaticcancer cells may be of importance in the pathobiology of this disorder.