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Rebecca Sadler
Researcher at Ludwig Maximilian University of Munich
Publications - 8
Citations - 782
Rebecca Sadler is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Microbiome & Gut flora. The author has an hindex of 6, co-authored 8 publications receiving 382 citations.
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Journal ArticleDOI
Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke.
Vikramjeet Singh,Stefan Roth,Gemma Llovera,Rebecca Sadler,Debora Garzetti,Bärbel Stecher,Martin Dichgans,Arthur Liesz +7 more
TL;DR: It is shown by next-generation sequencing that large stroke lesions cause gut microbiota dysbiosis, which in turn affects stroke outcome via immune-mediated mechanisms, and that the gut microbiota is a central regulator of immune homeostasis.
Journal ArticleDOI
Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms
Rebecca Sadler,J. Cramer,Steffanie Heindl,Sarantos Kostidis,Dene M Betz,Kielen R Zuurbier,Bernd H. Northoff,Marieke Heijink,Mark P. Goldberg,Erik J. Plautz,Stefan Roth,Rainer Malik,Martin Dichgans,Lesca M. Holdt,Corinne Benakis,Martin Giera,Ann M. Stowe,Ann M. Stowe,Arthur Liesz +18 more
TL;DR: Short-chain fatty acids, fermentation products of the gut microbiome, are potent and proregenerative modulators of poststroke neuronal plasticity at various structural levels and are identified as a potential therapeutic to improve recovery after stroke.
Journal ArticleDOI
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Alessio Colombo,Rebecca Sadler,Gemma Llovera,Vikramjeet Singh,Stefan Roth,Steffanie Heindl,Laura Sebastian Monasor,Aswin Verhoeven,Finn Peters,Samira Parhizkar,Frits Kamp,Mercedes Gomez de Agüero,Andrew J. Macpherson,Edith Winkler,Edith Winkler,Jochen Herms,Jochen Herms,Corinne Benakis,Martin Dichgans,Harald Steiner,Harald Steiner,Martin Giera,Christian Haass,Christian Haass,Sabina Tahirovic,Arthur Liesz +25 more
TL;DR: In this paper, the authors identify microbiota-derived short chain fatty acids (SCFA) as microbial metabolites which promote Alzheimer's disease (AD) deposition. But, the mechanisms of microbiome-brain interaction in AD were so far unknown.
Journal ArticleDOI
The gut microbiome primes a cerebroprotective immune response after stroke
Vikramjeet Singh,Rebecca Sadler,Steffanie Heindl,Gemma Llovera,Stefan Roth,Corinne Benakis,Arthur Liesz +6 more
TL;DR: Bacterial colonization increased cerebral expression of cytokines as well as microglia/macrophage cell counts in contrast to improved stroke outcome, which supports the concept of lymphocyte-driven protective neuroinflammation after stroke under control of the microbiome.
Journal ArticleDOI
Microbiota differences between commercial breeders impacts the post-stroke immune response.
Rebecca Sadler,Vikramjeet Singh,Corinne Benakis,Debora Garzetti,David Brea,Bärbel Stecher,Josef Anrather,Arthur Liesz +7 more
TL;DR: This study demonstrates the major impact of microbiota differences on T cell polarization in mice during ischemic stroke conditions, and following immunomodulatory therapies.